Amive Tablet 10/40 mg

Adult dosage

This medication is administered once daily regardless of meals. For primary hypercholesterolemia, the dosage range is 10/10 mg to 10/80 mg per day. An initial dose of 10/10 mg or 10/20 mg daily is recommended. In patients requiring a more significant reduction in LDL cholesterol (over 55%), an initial dose of 10/40 mg daily is recommended. Dose adjustments should be made after evaluating blood lipid levels at intervals of more than 2 weeks.

This medication has been reported to cause a serious side effect known as rhabdomyolysis, which can lead to acute kidney failure due to rare damage to muscle tissue. Therefore, in patients who exhibit severe myopathy symptoms or those at high risk for kidney failure such as those with severe infections, hypotension, or after major surgeries, this medication should be temporarily discontinued or stopped. This medication should not be used by individuals with allergies to the active ingredient or its components, those with severe liver dysfunction, muscle diseases, pregnant or potentially pregnant women, breastfeeding women, those taking certain antiviral medications, and individuals with lactose intolerance. Caution should be exercised in alcoholics or those with a history of liver disease, patients with severe liver dysfunction, those with impaired kidney function or hypothyroidism, and elderly individuals, who are at higher risk for myopathy; if muscle pain or weakness arises, immediate consultation with a physician is recommended. During treatment with this medication, side effects such as muscle pain, abdominal pain, and increased liver enzyme levels may occur, especially if liver dysfunction or muscle-related symptoms appear, which should be reported to medical personnel. Additionally, this medication can interact with several other drugs, so it is essential to inform your doctor or pharmacist if you are taking other medications. Caution is needed when used in combination with specific antibiotics, antivirals, and immunosuppressants as it may increase the risk of muscle damage. Pregnant or breastfeeding women should not take this medication, and women of childbearing potential should use appropriate contraception while taking it. The safety and efficacy of this medication in children have not been established and are therefore not recommended. Caution is warranted for elderly patients due to the higher risk of myopathy, though dose adjustment is generally not necessary. Patients with compromised liver or kidney function must consult with medical personnel before taking this medication, and if liver function abnormalities persist, use should be discontinued. In the case of overdose, there is no specific antidote, and treatment should focus on symptomatic support, with regular monitoring of liver function and muscle enzyme levels. This medication should be kept out of reach of children and should not be transferred to another container. If symptoms such as dizziness or muscle pain occur during treatment, caution should be exercised when operating vehicles or machinery.

Serious side effects

Hives, severe swelling (edema), liver abnormality (jaundice), Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), erythema multiforme, severe skin reactions including erythema multiforme, difficulty breathing, asthma, thrombocytopenia, anaphylaxis, liver failure, severe swelling or urination issues, severe myopathy, rhabdomyolysis, acute kidney failure, intracranial aneurysm, severe neurological symptoms (intracranial)

Mild side effects

• Muscle pain
• abdominal pain
• elevated liver enzymes
• dizziness
• cough
• nausea
• diarrhea
• joint pain
• muscle weakness
• musculoskeletal pain

This medication should be stored in a tightly sealed container to prevent air or moisture ingress and is best kept in a cool place below 30 degrees Celsius.

Appearance

White to off-white, oval, biconvex, film-coated tablet

Package unit

30 tablets/box - 10 tablets/plate [X3]