Combit 10/10 mg Tablet

Adult dosage

This medication is administered once daily, regardless of meals. The dosage range for primary hypercholesterolemia is 10/10 mg to 10/80 mg per day, with a recommended initial dose of 10/10 mg or 10/20 mg per day. For patients who require a greater reduction in LDL cholesterol, an initial dose of 10/40 mg per day is recommended. After starting therapy or adjusting the dose, serum lipid levels should be checked at intervals of more than 2 weeks.

This medication has been reported to cause a rare side effect called rhabdomyolysis, which can lead to serious muscle damage. Therefore, if severe muscle pain or weakness occurs, it is essential to consult a doctor immediately. Additionally, this medication should not be given to patients with liver dysfunction or liver disease, and liver function tests must be conducted before administration. Women who are pregnant or may become pregnant, as well as breastfeeding women, should not use this medication. This drug may increase the risk of side effects when taken with certain medications, so inform your doctor or pharmacist if you are taking other medicines. Elderly patients or those with impaired kidney function also require caution when taking this drug, and regular testing and monitoring are recommended. During treatment, symptoms such as dizziness, muscle pain, abdominal pain, or liver function abnormalities may occur, so inform medical personnel immediately if these symptoms arise. This medication is not recommended for children as its safety and efficacy have not been established.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, mucosal pain in the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, vision disturbances, paralysis, urination

Mild side effects

• Muscle pain
• abdominal pain
• elevated liver enzymes
• dizziness
• cough
• nausea
• diarrhea
• joint pain
• muscle weakness
• musculoskeletal pain

This medication should be stored in a tightly closed container to protect it from air and moisture. It is recommended to keep the medication at room temperature between 1°C and 30°C, away from extreme heat or cold.

Appearance

White, oblong film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP packaging (Alu-Alu) x 3]