Arotin Plus Tablets 10/40 mg (Ezetimibe/Atorvastatin Calcium Trihydrate)

Adult dosage

This medication is administered once daily without regard to meals. For primary hypercholesterolemia, the dosage range is between 10/10 mg and 10/80 mg daily, with an initial recommended dose of 10/10 mg or 10/20 mg daily. If a significant reduction in LDL cholesterol is needed, an initial dose of 10/40 mg daily is recommended. After starting treatment or adjusting the dose, lipid levels should be checked after an interval of more than two weeks.

This medication is used to lower blood cholesterol levels. There is a risk of muscle problems, so if you experience severe muscle pain or weakness, you should inform your doctor immediately. Due to the possibility of kidney issues from muscle damage, this medication may be temporarily discontinued if there are pre-existing kidney or liver diseases, or in situations involving serious infections, trauma, or after surgery. Patients with liver dysfunction or persistently elevated liver enzymes should not take this medication. Individuals who are allergic to any of the components of this medication, those with muscle diseases, and women who are pregnant or breastfeeding should not use this medication. This medication should not be taken in conjunction with certain antiviral agents or fibrate medications, so anyone taking other medications should inform their healthcare provider without fail. Patients who consume alcohol excessively, have a history of liver disease, elderly patients, and those with hypothyroidism should use this medication cautiously and may require regular monitoring. Regular liver function tests and muscle-related tests should be conducted during the treatment, and any unusual symptoms must be discussed with healthcare professionals immediately. Caution is advised when driving or operating machinery due to the possibility of dizziness. Women planning to become pregnant should consult healthcare professionals before starting this medication and should use appropriate contraceptive methods during treatment. There are numerous drug interactions, so it is crucial to inform healthcare professionals of any other medications being taken and to consult regarding dosages or alternative medications. There is no specific antidote for overdose, so appropriate treatment and supportive care are necessary based on symptoms, and liver function and muscle conditions should be monitored. This medication has not been established for safety and efficacy in children and is not recommended.

Serious side effects

Rash, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), erythema multiforme, cholestatic jaundice, jaundice, hepatitis, liver failure, acute renal failure, renal failure, severe edema, hypertension accompanied by

Mild side effects

• Muscle pain
• abdominal pain
• nausea
• diarrhea
• joint pain
• muscle weakness
• musculoskeletal pain
• dizziness
• headache
• hyperkalemia

This medication should be stored in a tightly closed container to prevent exposure to air and humidity, ideally at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's effectiveness over a longer period.

Appearance

White or whitish oblong film-coated tablets

Package unit

30 tablets/box [(10 tablets/PTP x 3)]