Glucita Tablet 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. For patients with renal impairment, dosage adjustments are necessary; mild and moderate renal impairment do not require dosage adjustments. For moderate renal impairment (eGFR 30–45 mL/min/1.73 m²), 50 mg is administered once daily. For severe renal impairment (eGFR 15–30 mL/min/1.73 m²) or those requiring dialysis or peritoneal dialysis for end-stage renal disease (ESRD) (eGFR < 15 mL/min/1.73 m²), 25 mg is administered once daily.

This medication may rarely cause serious allergic reactions; therefore, if symptoms such as skin rash or difficulty breathing occur, it is necessary to discontinue use immediately and consult a physician. While taking this medication, inflammation of the pancreas known as pancreatitis may occur, so if severe abdominal pain or vomiting develops, notify medical personnel immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, and those allergic to this medication or its components should also avoid it. Patients with impaired kidney function may need dosage adjustments, so regular kidney function tests should be conducted, and the medication should be taken according to a physician's guidance. Hypoglycemic symptoms may occur when taking this medication alone or in combination with other diabetes medications, so monitor for signs of hypoglycemia and measure blood sugar frequently as needed. When taken with insulin or sulfonylurea, the risk of hypoglycemia may increase, hence physicians may recommend dosage adjustments. If symptoms such as severe joint pain or skin blisters develop, notify a physician immediately, and use of the medication may need to be discontinued in such cases. It is not recommended for pregnant or breastfeeding women to take this medication; consultation with a physician is essential before use. In elderly patients, diminished kidney function is common; therefore, kidney function should be regularly monitored with caution while using this medication. In the event of overdose, immediate medical attention should be sought for appropriate treatment, and this medication may be partially removed by dialysis. This medication has minimal significant interactions with many other medications, but inform the physician about any other medications being taken, as concentration changes in the blood may occur.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction), severe rash with high fever, blisters, peeling skin, oral/ocular mucosal pain (severe cutaneous adverse reactions), acute pancreatitis (fatal/non-fatal hemorrhagic or necrotizing), severe edema or urinary issues (acute renal failure), severe joint pain with complications, bullous pemphigoid, sudden

Mild side effects

• Hypoglycemia
• upper respiratory infection
• rhinitis
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• myalgia

Store this medication in an airtight container that does not allow air to pass through, and it is recommended to keep it at room temperature between 1 and 30 degrees Celsius. This way, the effectiveness of the medication can be well maintained.

Appearance

Pink, round, biconvex film-coated tablets

Package unit

28 tablets/box [(14 tablets/PTP×2)]