Egliptin Tablets 25 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg as monotherapy or in combination, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Patients with renal impairment require dosage adjustments based on kidney function. - Mild renal impairment: No dosage adjustment needed - Moderate renal impairment (eGFR 45–60 mL/min/1.73 m2): No dosage adjustment needed - Moderate renal impairment (eGFR 30–45 mL/min/1

This medication is used for treating diabetes, and some patients may experience serious allergic reactions. These reactions can occur within 3 months of starting the medication, so caution is warranted. During treatment, inflammation of the pancreas (pancreatitis) may develop, so if symptoms such as abdominal pain or vomiting occur, consult a doctor immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in individuals with allergies to this drug or its components. Patients with impaired kidney function may need to adjust the dosage of this medication, so regular kidney function tests are recommended. In clinical trials, this medication exhibited safety similar to placebo; however, side effects such as pharyngitis, headache, upper respiratory tract infection, and diarrhea were reported. Particularly when taken with insulin or sulfonylureas, the risk of hypoglycemia may increase, so caution is advised. If severe joint pain or skin blisters develop while taking this medication, consult a doctor immediately and discontinue use. Pregnant women are advised not to use this medication, and breastfeeding women should also avoid it. Elderly patients may have reduced kidney function; therefore, dosage adjustments and monitoring of kidney function are necessary. In the event of overdose, standard emergency treatment should be applied, and if needed, some drugs can be removed through hemodialysis. This medication generally has low drug interaction potential when combined with other blood glucose-lowering agents; however, consultation with a doctor is needed when taken with certain medications. This medication has been confirmed to not increase cardiovascular risk in cardiovascular safety trials.

Serious side effects

Hypersensitivity reactions (urticaria, angioedema), anaphylaxis, Stevens-Johnson syndrome (severe cutaneous adverse reactions), acute pancreatitis, acute renal failure, bullous pemphigoid, severe and disabling arthralgia, severe allergic reactions, hypoglycemia (in severe cases), elevated liver enzymes, liver abnormalities (caution in suspected jaundice), pneumonia, diabetic complications, metabolic acidosis, cardiac arrest

Mild side effects

• Nasopharyngitis
• upper respiratory tract infection
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• myalgia
• limb pain

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is advisable to maintain storage temperatures between 1 degree and 30 degrees Celsius. This storage method helps preserve the drug's efficacy and safety.

Appearance

Pink, round, biconvex film-coated tablet

Package unit

PTP - 28 tablets/PTP [(14 tablets/PTP × 2)]