Januum Tablet 100 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

This medication is administered at a dose of 100 mg once daily for monotherapy or combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. In patients with renal impairment: - Mild renal impairment (estimated glomerular filtration rate [eGFR] ≥ 60 and < 90 mL/min/1.73 m2) does not require dose adjustment. - Moderate renal impairment (estimated glomerular filtration rate [eGFR] ≥ 45 and < 60 mL/min/1.73 m2) does not require dose adjustment.

This medication may cause serious allergic reactions; therefore, if symptoms such as skin rash, difficulty in breathing, or swelling of the face or neck occur within 3 months of use, discontinue use immediately and consult a doctor. This medication may cause pancreatitis, an inflammation of the pancreas; if symptoms such as abdominal pain, vomiting, or loss of appetite occur, notify healthcare personnel immediately. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and it should not be administered to individuals with an allergy to this medication or its components. In patients with impaired renal function, the dosage of this medication should be adjusted, and regular kidney function tests should be performed according to the physician's instructions. Hypoglycemia may occur when this drug is used alone or in combination with other diabetes drugs, especially when taken with insulin or sulfonylureas, so it is important to carefully monitor blood glucose levels. If severe joint pain or skin blistering occurs, notify the physician immediately and discontinue use of this medication to receive appropriate treatment. Women who are pregnant or breastfeeding should avoid using this medication, and safety and efficacy have not been established in children under 18 years of age. Elderly patients may have reduced renal function, so renal function should be assessed before and during treatment, and dosage adjustments may be necessary. In case of overdose, seek medical treatment immediately, and this medication can be partially removed by hemodialysis. Drug interactions are generally minimal when taken with other medications; however, inform healthcare personnel and monitor if taken with cyclosporine or digoxin.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, exfoliative skin disorders (including Stevens-Johnson syndrome), acute pancreatitis, difficulty breathing, bullous pemphigoid, elevated liver enzymes (signs of liver dysfunction), acute renal failure, severe and disabling joint pain, cardiac arrest

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• dyspepsia
• dizziness
• constipation
• vomiting
• muscle pain

This medication should be stored in a tightly sealed container to prevent air from entering, and it is best kept at a temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the efficacy of the medication.

Appearance

Bright brown, round, bilaterally convex film-coated tablets

Package unit

28 tablets/box [14 tablets/PTP×2]