Sitaglm 25 mg Tablet (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg either as monotherapy or in combination, with the maximum daily dose of 100 mg. It can be taken regardless of meals. For patients with kidney impairment, dose adjustments according to kidney function are necessary. No dose adjustment is needed in mild and moderate kidney impairment (eGFR 45 or higher, but less than 90). For moderate kidney impairment (eGFR 30 or higher but less than 45), the dose is 50 mg once daily.

This medication may rarely cause serious allergic reactions. Such reactions can include anaphylaxis, angioedema, and severe skin conditions. Symptoms may appear within the first 3 months of taking the drug, so caution is necessary. If an allergic reaction is suspected, stop taking the medication immediately and consult a healthcare professional. Moreover, this medication can cause serious side effects, such as acute pancreatitis, which involves inflammation of the pancreas, so if symptoms like abdominal pain, vomiting, or loss of appetite occur during treatment, prompt medical attention is necessary. This medication is not to be used by patients with type 1 diabetes or diabetic ketoacidosis. Also, patients who are allergic to this drug or its components should not take it. For patients with reduced kidney function, dose adjustment is necessary, and regular kidney function tests are important. Common side effects reported in clinical trials include upper respiratory infection, nasopharyngitis, headache, diarrhea, etc., and symptoms of hypoglycemia may occur, so blood sugar management must be monitored closely. Especially when taken with insulin or sulfonylureas, the risk of hypoglycemia may increase, so dose adjustments for these medications may be needed. This medication is not recommended during pregnancy, and it is also advisable for breastfeeding women to avoid taking it. For elderly patients, dose adjustments and monitoring of kidney function are necessary due to the potential for decreased kidney function. In case of overdose, appropriate treatment such as gastrointestinal decontamination and ECG monitoring should be undertaken, and some may be removed by hemodialysis. If symptoms like joint pain or skin blisters or rash occur during treatment, notify healthcare professionals immediately, and if necessary, consider stopping the medication and consulting a specialist. This medication has a low potential for interactions with other medications; however, monitoring is necessary when taking digoxin. Lastly, this medication poses no issues concerning cardiovascular safety and does not increase the risk of heart disease with long-term use.

Serious side effects

Hives, severe swelling (angioedema), chest tightness (including difficulty breathing), difficulty breathing, cold sweat, pallor, anaphylaxis, severe skin adverse reactions (including Stevens-Johnson syndrome), acute pancreatitis, liver abnormalities (jaundice), severe neurological symptoms (headache, seizures, confusion, etc.), severe edema or urination issues, acute renal failure, severe and disabling joint pain, bullous pemphigoid, thrombocytopenia,

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• dyspepsia
• nausea
• constipation
• myalgia
• limb pain
• back pain

This medication should be kept in a tightly closed container to avoid exposure to air or humidity, and it is best stored at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

Pink, biconvex, round film-coated tablet

Package unit

28 tablets/PPT[(14 tablets/PTPx2)]