Sitagliptin Tablets 100 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

This medication is administered once a day at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. This medication can be taken without regard to meals. For patients with renal impairment: 1. Mild renal impairment (eGFR ≥ 60 and < 90 mL/min/1.73 m2) does not require dose adjustment. 2. Moderate renal impairment (eGFR ≥ 45 and < 60...

This medication may cause severe allergic reactions; therefore, if symptoms such as skin rash or difficulty breathing occur after administration, discontinue use immediately and seek medical attention. This medication can cause severe inflammation of the pancreas (pancreatitis), so if symptoms such as abdominal pain, nausea, or vomiting occur during use, notify a doctor immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should also be avoided in individuals with allergies to this medication or its ingredients. Patients with decreased renal function may have delayed excretion of this medication, necessitating dose adjustment or careful use. Adverse reactions reported in clinical trials include upper respiratory infections, headaches, nasopharyngitis, diarrhea, among others. There may be an increased risk of hypoglycemia when taken with insulin or sulfonylureas. This medication has relatively few drug interactions, but caution is required when taken with cyclosporine or digoxin, and appropriate monitoring is advised. Its safety has not been established in pregnant or breastfeeding women, and its safety and efficacy in children under 18 have not been confirmed. In elderly patients, renal function decline is common, thus regular evaluation of renal function should be performed before and during administration of this medication. In case of overdose, general emergency treatments should be applied, and consideration can be given to blood dialysis since some may be removed by it if necessary. If any unusual symptoms occur during medication, such as joint pain or blisters on the skin, consult a doctor immediately for appropriate measures.

Serious side effects

• Hives
• severe swelling (angioedema)
• anaphylaxis
• rash
• Stevens-Johnson syndrome
• exfoliative skin disease
• acute pancreatitis
• acute renal failure
• severe and disabling joint pain
• bullous pemphigoid

Mild side effects

• Nasopharyngitis
• upper respiratory infections
• headache
• diarrhea
• nausea
• constipation
• muscle pain
• limb pain
• back pain
• pruritus

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture and is best kept at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness.

Appearance

Bright brown, round, bilayered, convex film-coated tablets

Package unit

28 tablets/box [(14 tablets/PTP x 2)]