Sitagliptin 50 mg Tablets (Sitagliptin Hydrochloride Hydrate)

Adult dosage

This medication is administered once daily at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken independently of meals. Dosage for patients with renal impairment: 1. In mild renal impairment (glomerular filtration rate 60-90 mL/min/1.73 m²), no dosage adjustment is necessary. 2. In moderate renal impairment (glomerular filtration rate 45-60 mL/min/1.73 m²), no dosage adjustment is necessary.

This medication may cause severe allergic reactions, so if symptoms such as skin rash or difficulty breathing occur within 3 months of starting treatment, it should be discontinued immediately, and a physician must be consulted. During treatment, there is a risk of developing severe inflammation of the pancreas (pancreatitis); therefore, if symptoms such as abdominal pain, vomiting, or fever occur, immediate consultation with medical personnel is required. Patients with type 1 diabetes or diabetic ketoacidosis should not take this medication, nor should those with severe allergies to this medication or any of its ingredients. Patients with decreased kidney function may need dosage adjustments and should undergo regular kidney function testing. There is an increased risk of hypoglycemia when this medication is combined with other diabetes therapies, so if used alongside insulin or sulfonylureas, blood sugar should be carefully monitored, and dosage adjustment may be necessary. While taking this medication, symptoms such as headaches, upper respiratory infections, rhinitis, diarrhea, abdominal pain, constipation, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, dyspepsia, dizziness, increased blood triglycerides, gastritis, weight loss, hypertension, hypernatremia, and erectile dysfunction may occur; if symptoms are severe or persistent, consult a doctor. Pregnant women should avoid this medication as safety has not been established, and nursing women are also discouraged from use as this medication may be excreted in breast milk. The use of this medication in children and adolescents under 18 years of age is not advisable as safety and efficacy have not been confirmed. The elderly may experience reduced kidney function, so regular kidney function tests should be performed before and after taking this medication, and dosage should be adjusted carefully. In case of overdose, general emergency treatment should be implemented; if necessary, blood dialysis may be used to remove some of the medication. During treatment, if symptoms such as arthralgia or skin blistering occur, inform the doctor immediately and consider discontinuing the medication. Also, this medication may interact with certain drugs; therefore, it is essential to inform medical personnel if other medications are being taken.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, Stevens-Johnson syndrome and exfoliative skin conditions, severe rash with fever and blistering resembling bullous pemphigoid, acute pancreatitis, acute renal failure, severe and disabling arthralgia, elevated liver enzymes and hepatic abnormalities (jaundice not specified in documentation but may be related to liver abnormalities), severe edema accompanied by elevated blood pressure, severe allergic reactions, severe hypoglycemia, cardiac arrest

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• nausea
• diarrhea
• abdominal pain
• constipation
• myalgia
• limb pain
• back pain

This medication should be stored in a sealed container to protect it from air and humidity, ideally at room temperature between 1 degree and 30 degrees Celsius. Doing so helps maintain the medication's effectiveness.

Appearance

Light apricot-colored, round, biconvex film-coated tablet

Package unit

28 tablets/box [14 tablets/PTP x 2]