Januglyze Tablet 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg in either monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken with or without meals. Patients with renal impairment require dose adjustments according to renal function. - Mild renal impairment (eGFR 60 to less than 90): no dose adjustment required. - Moderate renal impairment (eGFR 45 to less than 60): no dose adjustment required. - Moderate renal impairment (eGFR 30 to less than 45): administer 50 mg once daily. - Severe renal impairment (eGFR 15 to less than 30) or patients requiring dialysis (ESRD) (eGFR < 15): administer 25 mg once daily. This medication can be administered regardless of dialysis timing.

This medication can rarely cause serious allergic reactions. Symptoms may include skin peeling or swelling of the face or neck. Such symptoms can appear within 3 months of starting this medication, so careful observation is necessary. If allergic symptoms are suspected, discontinue the medication immediately and consult a doctor. Additionally, this medication can cause serious side effects such as pancreatitis, which is inflammation of the pancreas. If pancreatitis is suspected, stop taking the medication and inform your healthcare provider immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor should it be administered to those who have an allergy to this medication or its components. Patients with impaired kidney function need dosing adjustments for this medication. In particular, patients with low glomerular filtration rate or those undergoing dialysis are recommended to adjust the dosage to a lower amount. Using this medication may result in side effects such as cold-like symptoms, headache, indigestion, diarrhea, constipation, vomiting, muscle pain, limb pain, back pain, itching, thrombocytopenia, blistering dermatitis, hypoglycemia, indigestion, dizziness, increased ALT, increased AST, increased blood triglycerides, hyperglycemia, hypernatremia, weight loss, hypertension, and erectile dysfunction. If hypoglycemic symptoms occur, blood glucose should be checked immediately and appropriate measures should be taken as necessary. This medication is not recommended for use in pregnant women, and breastfeeding mothers should also avoid taking it. Safety in children or adolescents under 18 years has not been established. For the elderly, kidney function may decline, so it's important to regularly monitor renal function before and during treatment. In cases of overdose, general emergency treatments should be administered, and if necessary, this medication can be removed through hemodialysis. If symptoms of joint pain or skin blistering occur while taking this medication, consult a physician immediately, and discontinuation of the medication may be necessary depending on the situation. Finally, this medication does not have significant interactions with several other medications; however, there can be changes in blood concentration with specific medications, so inform your healthcare provider of any other medications you are taking.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, paleness (severe allergic reaction), severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain (severe skin reactions), difficulty breathing or wheezing, asthma attacks, cough accompanied by fever and respiratory issues (respiratory problems), yellowing of the skin or eyes (jaundice), severe lethargy (liver dysfunction), sudden serious allergic reactions.

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air ingress, and it is best to keep it at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness for a long time.

Appearance

Pink, round, biconvex film-coated tablet

Package unit

PTP - 28 tablets/box [(14 tablets/PTP × 2)], bottle - 30 tablets/bottle, bottle - 90 tablets/bottle