Januglycia 100 mg (Sitagliptin hydrochloride monohydrate)

Adult dose

This medication is administered as a single daily dose of 100 mg, whether as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. This drug can be taken regardless of meals. For patients with renal impairment, dosage adjustments may not be necessary for mild to moderate renal impairment. In moderate renal impairment (glomerular filtration rate 30–45 mL/min/1.73 m2), a dose of 50 mg is administered once daily.

This drug may cause severe allergic reactions, so if symptoms such as skin rash or difficulty breathing occur, you must stop taking it immediately and consult a physician. There is a risk of acute pancreatitis occurring during treatment, so symptoms such as abdominal pain, vomiting, or loss of appetite should be monitored closely. Patients with type 1 diabetes or diabetic ketoacidosis should not take this medication. Those allergic to this drug or its ingredients should not take it. Patients with decreased kidney function need to adjust the dosage of this medication, and regular kidney function tests are important. Symptoms similar to a cold, headaches, diarrhea, nausea, etc. may occur during treatment. When combined with insulin or sulfonylureas, there is an increased risk of hypoglycemia, so blood sugar changes should be monitored closely and drug dosages adjusted as necessary. This drug may cause rare side effects such as severe joint pain or blistering skin diseases, so inform your doctor immediately if joint pain or skin abnormalities occur. Use of this drug is not recommended for pregnant or lactating women. In case of overdose, you should visit a medical institution immediately for appropriate treatment, and this drug can be partially removed via dialysis. This drug has fewer drug interactions, but it is advisable to consult with a physician or pharmacist when taking it with specific medications. Elderly patients may have decreased kidney function, so kidney function tests should be performed before taking this medication, and dosage adjustments may be necessary.

Serious side effects

Urticaria, severe swelling (angioedema), severe allergic reactions, severe hypersensitivity reactions, anaphylaxis, Stevens-Johnson syndrome and exfoliative skin diseases, severe skin reactions, blistering erythema multiforme (including blistering erythema multiforme), acute pancreatitis, liver abnormalities (elevated liver enzymes, potential jaundice), acute renal failure, respiratory issues (interstitial lung disease), severe joint pain with disability, severe neurological symptoms (cardiac arrest)

Mild side effects

• Headache
• upper respiratory tract infection
• nasopharyngitis
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• myalgia
• limb pain

This medication should be stored in a tightly sealed container to prevent air exposure, and it is best to store it at room temperature between 1 degree and 30 degrees Celsius. This storage method helps maintain the drug's efficacy and prevents degradation.

Appearance

Light brown, round, biconvex film-coated tablet

Package unit

PTP - 28 tablets/box [(14 tablets/PTP×2)], bottle - 30 tablets/bottle, bottle - 90 tablets/bottle