Arikotok Soft Capsule 10mg (Alitretinoin)

Adult dose

Take 10~30mg once daily with or immediately after a meal. It is preferable to take it at the same time every day. The initial dose is 30mg of alitretinoin; reduce the dose to 10mg according to adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia: The initial dose is 10mg and may be increased to 30mg as needed depending on tolerability and efficacy. Periodic monitoring of the blood lipid profile and blood glucose may be necessary during treatment with this medicine. Discontinue treatment as soon as the treatment goal of clear or almost clear hands is achieved. Discontinue treatment if hand eczema remains severe after the initial 12 weeks of treatment, and also discontinue treatment if the treatment goal has not been achieved by 24 weeks of treatment.

This medication poses a very high risk of serious congenital malformations to the fetus if taken during pregnancy; therefore, women who are pregnant or may become pregnant must not take this medication. Women taking this medication must use two or more effective methods of contraception from the start of treatment until one month after the end of treatment, and must undergo regular pregnancy tests. If blood triglyceride levels are very high, acute pancreatitis may occur, therefore cholesterol and triglyceride levels should be monitored periodically during treatment with this medication. If there are any mental health issues or a history of depression, symptoms may worsen while taking this medication, so mental state should be carefully monitored and treated as necessary. This medication should not be administered to patients with severely impaired liver or kidney function, those with uncontrolled thyroid function, or patients with hypervitaminosis A. During treatment, excessive sun exposure should be avoided, sunscreen should be used, and vigorous exercise should be avoided for safety. Dry eyes or visual disturbances may occur, so if these symptoms arise, consult a doctor immediately, and wearing eyeglasses may be necessary as contact lens use might be difficult. There may be interactions with other medications, so it is essential to inform your doctor or pharmacist of any other drugs being taken, and particularly tetracycline antibiotics should not be taken together. This medication should be swallowed with water during or immediately after meals, and care should be taken to avoid chewing the capsule. Store this medication out of the reach of children, away from direct sunlight at temperatures below 30 degrees Celsius. Possible adverse reactions during use include headache, skin rash, dry lips, increased triglycerides, so consult a doctor if symptoms are severe. Participation in a pregnancy prevention program and closely following the guidance of a doctor and pharmacist is crucial, and if pregnancy is confirmed during or within one month after treatment, treatment should be discontinued immediately and evaluated by a specialist.

• Headache
• erythema
• flushing
• increased triglycerides
• increased cholesterol
• decreased thyroid-stimulating hormone
• decreased free T4
• anemia
• increased iron-binding capacity
• decreased monocytes

This medication is sensitive to light, so it should be stored in a container that does not allow light to enter. Also, to maintain effectiveness, it is important to store it in a cool place below 30 degrees Celsius.

Appearance

Brown oval soft capsule containing yellow oily contents

Package unit

30 capsules/box [10 capsules/PTP×3]