Medication info
Aritok Soft Capsules 30 mg (Alitretinoin)

Aritok Soft Capsules 30 mg (Alitretinoin)

Prescription medicationSoft capsuleOral
Ingredient · strength
Alitretinoin›30mg / 1 capsule
Manufacturer / importer
The U Pharmaceutical Co., Ltd.
Appearance
Brown oval soft capsules containing yellow oily contents
Packaging
30 capsules/box [(10 capsules / PTP X 3)]
Approval status
Active

MFDS item code 202100495 · Approved 2021.01.18 · Insurance code 057001590

Summary

Main use
Treatment of chronic severe hand eczema in adults that has not responded to topical corticosteroids
Who takes it
Adults
Adult dose
Take 10~30mg once daily with or immediately after a meal. It is preferable to take it at the same time every day. The initial dose is 30mg of alitretinoin; reduce the dose to 10mg according to adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia: The initial dose is 10mg and may be increased to 30mg as needed depending on tolerability and efficacy. Periodic monitoring of the blood lipid profile and blood glucose may be necessary during treatment with this medicine. Discontinue treatment as soon as the treatment goal of clear or almost clear hands is achieved. Discontinue treatment if hand eczema remains severe after the initial 12 weeks of treatment, and also discontinue treatment if the treatment goal has not been achieved by 24 weeks of treatment.

Ingredients

Manufacturer
The U Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of chronic severe hand eczema in adults that has not responded to topical corticosteroids

  • Chronic severe hand eczema
View approved original text

This medication is used to treat chronic severe hand eczema in adults that has not responded to at least 4 weeks of potent topical steroid treatment.

How to take

Adult dose

Take 10~30mg once daily with or immediately after a meal. It is preferable to take it at the same time every day. The initial dose is 30mg of alitretinoin; reduce the dose to 10mg according to adverse reactions. Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia: The initial dose is 10mg and may be increased to 30mg as needed depending on tolerability and efficacy. Periodic monitoring of the blood lipid profile and blood glucose may be necessary during treatment with this medicine. Discontinue treatment as soon as the treatment goal of clear or almost clear hands is achieved. Discontinue treatment if hand eczema remains severe after the initial 12 weeks of treatment, and also discontinue treatment if the treatment goal has not been achieved by 24 weeks of treatment.

Precautions

This medication must not be used by women who are pregnant or may become pregnant, as it can cause serious fetal malformations. During the treatment, at least two effective contraceptive methods must be used, and regular pregnancy tests should be performed before, during, and after treatment. Blood triglyceride and cholesterol levels should be monitored periodically, and if any abnormalities are detected, the doctor should be consulted immediately. Notably, very high triglyceride levels can lead to serious problems like acute pancreatitis. Attention should also be paid to mental health, as this medication may cause psychiatric symptoms such as depression, mood changes, and suicidal thoughts, so inform healthcare professionals immediately if there is a history of mental illness or symptoms appear. The skin may become dry or lips may crack, so use moisturizers, and seek appropriate treatment if the eyes become dry or vision issues occur. Prolonged exposure to strong sunlight can worsen skin reactions, so avoid sunlight and use sunblock. This medication should not be used in patients with specific conditions, such as those with severely impaired liver or kidney function, uncontrolled hypothyroidism, or patients with hypervitaminosis A. There may be interactions with other medications, so inform the doctor or pharmacist of any medications being taken, especially tetracycline antibiotics should not be taken together. This medication should be taken with food or immediately after meals, and it should be swallowed whole with water without chewing. Children and adolescents are advised not to take this medication. Finally, this medication should be taken strictly according to the doctor's instructions, and participate in pregnancy prevention programs to use it safely.

Side effects

  • Headache
  • erythema
  • flushing
  • increased triglycerides
  • increased cholesterol
  • decreased thyroid-stimulating hormone
  • decreased free T4
  • anemia
  • increased iron binding capacity
  • decreased monocytes
Show 62 more
  • increased platelets
  • anaphylactic reaction
  • hypersensitivity reaction
  • depression
  • mood changes
  • suicidal thoughts
  • dizziness
  • benign intracranial hypertension
  • conjunctivitis
  • dry eyes
  • eye irritation
  • blurred vision
  • cataract
  • decreased night vision
  • tinnitus
  • hypertension
  • vasculitis
  • nosebleeds
  • nausea
  • dry mouth
  • vomiting
  • indigestion
  • inflammatory bowel disease
  • increased aminotransferases
  • dry skin and lips
  • cheilitis
  • eczema
  • dermatitis
  • hair loss
  • itching
  • rash
  • skin peeling
  • xerotic eczema
  • nail disorders
  • phototoxic reactions
  • hair texture abnormalities
  • arthralgia
  • myalgia
  • osteomalacia
  • ankylosing spondylitis
  • fatigue
  • peripheral edema
  • hypertriglyceridemia
  • decreased HDL
  • hypercholesterolemia
  • increased serum creatine phosphokinase
  • diabetes
  • color blindness
  • intolerance to contact lenses
  • premature epiphyseal closure
  • hyperostosis
  • calcification of ligaments and tendons
  • corneal opacity
  • keratitis
  • inflammatory bowel disease
  • skin allergic reactions
  • anaphylactic reaction
  • purpura
  • severe allergic vasculitis
  • erythema multiforme
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light and should be stored in a dark container to prevent light exposure. Also, it is best to store it in a cool place at a temperature below 30 degrees Celsius.

Appearance and packaging

Appearance

Brown oval soft capsules containing yellow oily contents

Package unit

30 capsules/box [(10 capsules / PTP X 3)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.