Tostjet Tablets 10/40 mg

Adult dosage

This medication is administered once daily, regardless of meals. For primary hypercholesterolemia, the dosage range is 10/10 mg to 10/40 mg per day. An initial dose of 10/10 mg or 10/20 mg per day is recommended. If greater reduction in LDL cholesterol is needed, the dose may be adjusted. After confirming lipid levels at an interval of more than 2 weeks, the dosage may be modified accordingly.

This drug has been reported to cause a rare side effect called rhabdomyolysis, which can result in serious muscle damage. Particularly in the presence of risk factors such as acute infection, hypotension, major surgery, trauma, and metabolic disorders, the medication should be temporarily discontinued or stopped. Patients allergic to any component of this drug or those with liver disease, muscle disease, pregnant or breastfeeding women, or those taking certain other medications should not use this drug. Alcoholics, patients with liver function impairment, patients with reduced kidney function or hypothyroidism should use this drug with caution. Additionally, elderly patients over 70 years of age or those with a history of muscle toxicity also require special attention. If muscle pain, weakness, fatigue, or fever occurs during treatment with this drug, the physician should be notified immediately as blood tests may be needed to check for muscle damage. Liver function could be impaired, thus liver function tests should be conducted before and during administration, and the medication should be discontinued if symptoms of liver damage arise. This drug should not be administered to women who are pregnant or may become pregnant, and suitable contraceptive measures should be taken during treatment. Breastfeeding women are also advised not to take this drug. The safety and efficacy of this drug in children have not been established, hence it is not recommended. Elderly patients are at higher risk for myopathy, so caution is necessary during administration. This drug may interact with other medications; therefore, if the patient is taking other drugs, it is essential to inform the physician or pharmacist. In cases of overdose, as there is no specific antidote, treatment should rely on symptoms and monitoring liver function and muscle damage indicators.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, peeling skin, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory problems accompanied by coughing + fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, lightning-type headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Headache
• dizziness
• paresthesia
• itching
• rash
• pruritus
• hives
• abdominal pain
• diarrhea
• nausea

This medication should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius to preserve the efficacy of the medication.

Appearance

White oval film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP*3]