Medication info
Tosjet Tablet 10/20 mg

Tosjet Tablet 10/20 mg

Prescription medicationTablet
Ingredient · strength
Atorvastatin Calcium›21.7mg / 1 tabletEzetimibe›10mg / 1 tablet
Manufacturer / importer
에스케이케미칼(주)
Appearance
White oval film-coated tablet
Packaging
30 tablets/box[(10 tablets/PTP*3)], 30 tablets/bottle
Approval status
Active

MFDS item code 202100237 · Approved 2021.01.08 · Insurance code 644704860

Summary

Main use
Lipid-lowering effect by reducing cholesterol and increasing HDL in hypercholesterolemia and dyslipidemia
Who uses it
Adults
Adult dosage
This medication is administered once daily, regardless of meals. For primary hypercholesterolemia, the dosage range is 10/10 mg to 10/40 mg daily, with a recommended initial dose of 10/10 mg or 10/20 mg. In patients needing more significant reductions in LDL-cholesterol, the dosage can be adjusted. After initiating treatment or adjusting the dose, blood lipid levels should be monitored at intervals of more than 2 weeks.

Ingredients

Manufacturer
에스케이케미칼(주)

Efficacy & effects

Lipid-lowering effect by reducing cholesterol and increasing HDL in hypercholesterolemia and dyslipidemia

  • Primary hypercholesterolemia
  • heterozygous familial hypercholesterolemia
  • non-familial hypercholesterolemia
  • mixed dyslipidemia
  • elevated total cholesterol
  • increased LDL-cholesterol
  • increased Apo B protein
  • increased triglycerides
  • increased non-HDL cholesterol
View approved original text

This medication lowers total cholesterol, LDL-cholesterol, Apo B, triglycerides, and non-HDL cholesterol levels in patients with primary hypercholesterolemia, especially heterozygous familial and non-familial hypercholesterolemia, as well as mixed dyslipidemia. Meanwhile, it increases HDL-cholesterol levels, helping to maintain healthy lipid status. This medication is used in conjunction with an appropriate diet and is administered when dietary adjustments or non-drug therapies are insufficient. Additionally, it is safely used in patients at high risk for cardiovascular disease, and it is crucial to thoroughly check for other causes of dyslipidemia before treatment. This medication effectively regulates blood lipid levels and is used to reduce the risk of atherosclerotic vascular disease and improve overall cardiovascular health.

Dosage and Administration

Adult dosage

This medication is administered once daily, regardless of meals. For primary hypercholesterolemia, the dosage range is 10/10 mg to 10/40 mg daily, with a recommended initial dose of 10/10 mg or 10/20 mg. In patients needing more significant reductions in LDL-cholesterol, the dosage can be adjusted. After initiating treatment or adjusting the dose, blood lipid levels should be monitored at intervals of more than 2 weeks.

Precautions

This medication may affect muscles and has a rare possibility of causing rhabdomyolysis, which can damage muscle tissue and lead to kidney dysfunction. During treatment with this medication, if you experience muscle pain, muscle cramps, muscle weakness, or fatigue with fever, you must inform your doctor immediately, and blood tests may be needed to check for muscle damage. Additionally, in cases of acute infections, hypotension, major surgery, trauma, or endocrine diseases that have a high risk of muscle damage, it may be necessary to temporarily discontinue or stop this medication. This medication should not be used in individuals with an allergy to its components, those with active liver disease, muscle disease, pregnant women or women of childbearing potential, nursing mothers, or those taking specific antiviral medications. Caution is advised when administering this medication to patients at higher risk of myopathy, such as those with impaired liver function, alcoholics, the elderly, and patients with hypothyroidism. Regular liver function tests and muscle-related tests are necessary. This medication may increase liver enzyme levels, so liver function tests should be performed before and during treatment, and treatment should be discontinued immediately if symptoms of liver damage occur. This medication may also increase blood glucose levels, so patients at risk for diabetes should manage their blood sugar levels diligently. When used in combination with other medications, the concentration of this medication in the blood may increase due to interactions, or the risk of side effects may rise; therefore, if you are currently taking other medications, you must consult your doctor or pharmacist. Women of childbearing age should use appropriate contraceptive methods while taking this medication, and treatment should be stopped immediately if pregnancy is confirmed. It is advisable for nursing mothers to refrain from taking this medication. Safety in children has not been established and is therefore not recommended. In cases of overdose, there is no specific antidote, so treatment should be symptomatic, and monitoring of liver function and muscle damage is important.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme general fatigue, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, vision abnormalities, paralysis, urination

Mild side effects

  • Fatigue
  • malaise
  • chest pain
  • peripheral edema
  • fever
  • nasopharyngitis
  • cough
  • itching
  • headache
  • dizziness
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  • paresthesia
  • hypertension
  • hyperglycemia
  • hypoglycemia
  • weight gain
  • loss of appetite
  • constipation
  • abdominal distension
  • dyspepsia
  • nausea
  • diarrhea
  • abdominal pain
  • vomiting
  • belching
  • pancreatitis
  • pharyngeal/laryngeal pain
  • nosebleeds
  • insomnia
  • nightmares
  • myalgia
  • arthralgia
  • limb pain
  • muscle cramps
  • joint swelling
  • back pain
  • neck pain
  • muscle fatigue
  • thrombocytopenia

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature.

Appearance and packaging

Appearance

White oval film-coated tablet

Package unit

30 tablets/box[(10 tablets/PTP*3)], 30 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.