Apeget Tablets 10/10 mg

Adult dosage

This medication is administered once daily regardless of meals. The dosage range is 10/10 mg to 10/40 mg per day. A starting dose of 10/10 mg or 10/20 mg once daily is recommended. For patients requiring a more significant reduction in LDL cholesterol, the dose can be adjusted accordingly. After determining the appropriate dose, lipid levels in the blood should be checked after intervals of more than 2 weeks and adjusted according to the results.

This medication has been reported to cause a rare side effect called rhabdomyolysis, which can cause serious muscle damage. Especially patients with severe myopathy or at risk of renal failure should temporarily discontinue or stop taking this medication. Patients with allergies to the active ingredients or components of this medication, those with active liver disease, muscle diseases, pregnant or breastfeeding women, patients taking certain antivirals, and those with lactose intolerance should not take this medication. Patients with a history of alcohol addiction or liver disease, those with severe liver impairment, patients prone to myopathy, elderly patients, and those taking specific medications should use this medication with caution. During the treatment with this medication, if symptoms such as muscle pain, fatigue, or muscle pain accompanied by fever occur, patients should immediately inform their doctor and undergo testing. Because liver function abnormalities may occur, liver function tests should be conducted before and during administration, and if symptoms of liver damage occur, the medication should be discontinued immediately. This medication is not to be used in pregnant or breastfeeding women, and women of childbearing age should use appropriate contraception during treatment. Additionally, safety and efficacy in children have not been established, hence its use is not recommended. Elderly patients and those with renal impairment are at higher risk of myopathy, so caution is needed. This medication may interact with other drugs, particularly with certain antibiotics, antivirals, fibrates, cyclosporine, etc., so the dosage should be adjusted according to the physician's instructions. There is no specific antidote for overdose, so treatment should be symptomatic and liver function and muscle enzyme tests should be performed and managed. Keep out of reach of children and ensure it is not transferred to another container.

Serious side effects

Hives, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), erythema multiforme, rhabdomyolysis, acute renal failure due to myoglobinuria, liver failure, jaundice, hemorrhagic stroke, severe edema, renal failure, intracranial aneurysm, restless leg syndrome, depression, bronchiolitis, dental abscess, vestibular neuritis, bradycardia, hypotension, anemia, hernia, hyperkalemia, vitamin D deficiency, cholecystitis.

Mild side effects

• Decreased sensation
• sensory abnormalities
• hypertension
• elevated ALT
• elevated GGT
• nasopharyngitis
• cough
• itching
• dizziness
• diabetes

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

White oval film-coated tablets

Package unit

30 tablets/box [10 tablets/PTP×3]