Medication info
Atofan Duo Tablet 10/20 mg

Atofan Duo Tablet 10/20 mg

Prescription medicationTablet
Ingredient · strength
Atorvastatin Calcium Hydrate›21.7mg / 1 tabletEzetimibe›10mg / 1 tablet
Manufacturer / importer
동국제약(주)
Appearance
White oval film-coated tablet
Packaging
30 tablets/box [10 tablets/PTP × 3], 30 tablets/bottle, 100 tablets/bottle
Approval status
Active

MFDS item code 202100226 · Approved 2021.01.08 · Insurance code 653404750

Summary

Main use
Improvement of cholesterol and lipid levels in hypercholesterolemia (primary, mixed) and dyslipidemia
Who uses it
Adults
Adult dosage
This medication is administered once daily regardless of meals. The dosage range is 10/10 mg to 10/40 mg per day. A starting dose of either 10/10 mg or 10/20 mg is recommended. If a greater reduction in LDL cholesterol is needed, the dosage can be adjusted. After starting the administration or adjusting the dosage, blood lipid levels should be checked at intervals of more than 2 weeks before dosage adjustments.

Ingredients

Manufacturer
동국제약(주)

Efficacy & effects

Improvement of cholesterol and lipid levels in hypercholesterolemia (primary, mixed) and dyslipidemia

  • Primary hypercholesterolemia
  • heterozygous familial hypercholesterolemia
  • non-familial hypercholesterolemia
  • mixed dyslipidemia
  • elevated total cholesterol
  • elevated LDL cholesterol
  • elevated Apo B protein
  • elevated triglycerides
  • elevated non-HDL cholesterol
View approved original text

This medication is used as an adjunct to diet in patients with primary hypercholesterolemia and mixed dyslipidemia to lower levels of total cholesterol, LDL cholesterol, Apo B, triglycerides, and non-HDL cholesterol, and to increase HDL cholesterol levels. It is prescribed in conjunction with a dietary regimen that includes restrictions on saturated fat and cholesterol intake and is administered when diet control or non-drug methods are insufficient. Additionally, this medication is used in the treatment of patients at high risk for atherosclerotic vascular disease due to hypercholesterolemia, and it should be considered along with multiple risk factors. Before starting treatment, any other causes of dyslipidemia, such as diabetes or hypothyroidism, should be identified and treated as necessary. Therefore, this medication is effectively used to improve blood lipid levels in the treatment of dyslipidemia.

Dosage and Administration

Adult dosage

This medication is administered once daily regardless of meals. The dosage range is 10/10 mg to 10/40 mg per day. A starting dose of either 10/10 mg or 10/20 mg is recommended. If a greater reduction in LDL cholesterol is needed, the dosage can be adjusted. After starting the administration or adjusting the dosage, blood lipid levels should be checked at intervals of more than 2 weeks before dosage adjustments.

Precautions

This medication can cause serious problems in muscles, so if symptoms such as muscle pain or weakness occur, a doctor should be notified immediately. In rare cases, this medication can cause muscle tissue destruction leading to kidney function issues, so caution is needed in patients with a history of kidney disease. Patients with poor liver function or a history of liver disease should consult with a doctor before taking this medication and should undergo regular liver function tests. This medication should not be taken by women who are pregnant or may become pregnant, or who are breastfeeding. Due to lactose content, patients with lactose intolerance should not take this medication. Caution should be exercised when consuming excessive alcohol or in cases of liver disease, as this may increase the risk of liver damage when taking this medication. Elderly patients (65 years and older) are at higher risk for muscle-related side effects, so careful monitoring is needed during administration. This medication may increase the risk of side effects when taken with certain other medications, so patients should inform their doctor or pharmacist of any other medications being taken. During treatment, liver function tests and blood muscle enzyme levels should be monitored regularly to detect any abnormal signs early. Dizziness or drowsiness may occur while taking this medication, so caution is needed when driving or operating machinery. Do not change or stop the dosage arbitrarily; take exactly as directed by your doctor. If any symptoms that are not suitable for you or unusual reactions occur, consult medical staff immediately.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash accompanied by high fever, blisters, skin peeling, pain in oral/eye mucous membranes, shortness of breath or difficulty breathing, asthma attack, breathing difficulties accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

  • Decreased sensation
  • altered sensation
  • hypertension
  • increased ALT
  • increased GGT
  • nasopharyngitis
  • cough
  • itching
  • dizziness
  • diabetes
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  • weakness
  • fatigue
  • chest pain
  • peripheral edema
  • tiredness
  • fever
  • hyperglycemia
  • hypoglycemia
  • weight gain
  • loss of appetite
  • constipation
  • abdominal bloating
  • dyspepsia
  • nausea
  • diarrhea
  • abdominal pain
  • vomiting
  • belching
  • pancreatitis
  • throat and larynx pain
  • nosebleed
  • insomnia
  • nightmares
  • headache
  • decreased sensation
  • altered taste
  • memory loss
  • speech

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to protect it from air and moisture, preferably at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication.

Appearance and packaging

Appearance

White oval film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP × 3], 30 tablets/bottle, 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.