Atovjet Tablets 10/10 mg

Adult dosage

This medication is taken once daily, regardless of meals. For primary hypercholesterolemia: administer within the dosage range of 10/10 mg to 10/80 mg per day. The recommended starting dose is 10/10 mg or 10/20 mg per day; in cases where a greater (more than 55%) reduction in LDL cholesterol is required, 10/40 mg per day is recommended. After starting the treatment or adjusting the dosage, check blood lipid levels at intervals of more than 2 weeks.

This medication may rarely cause a condition called rhabdomyolysis, leading to serious kidney problems due to muscle tissue damage. Patients with risk factors such as severe infections, low blood pressure, major surgery, trauma, severe metabolic disorders, or uncontrollable seizures should temporarily stop or discontinue this medication. It should not be used in patients with a known allergy to this drug, active liver diseases, persistently elevated liver enzyme levels of unknown origin, muscle disorders, pregnant or potentially pregnant women, nursing mothers, patients taking certain antiviral medications, or those with lactose intolerance. Caution is advised in patients prone to muscle problems, such as those with alcohol dependence, liver dysfunction, reduced kidney function or hypothyroidism, a history of genetic muscle diseases, or a history of muscle toxicity from statins or fibrates, and elderly patients over 70. Attention is also needed for patients taking fibrates or those with severe myasthenia gravis, as well as patients allergic to Yellow No. 4 (Tartrazine). While taking this medication, patients should immediately inform their doctor if they experience muscle pain, muscle cramps, muscle weakness, or muscle pain accompanied by fever or fatigue, and blood tests may be required to check for muscle damage. Liver function abnormalities may also arise, so liver function tests should be conducted before and during treatment; if symptoms of liver damage such as nausea, vomiting, or fatigue appear, the medication should be discontinued. This drug should not be administered to pregnant or nursing women, and women of childbearing age must use appropriate contraception. Caution is also warranted in the elderly or patients with impaired kidney function due to a high risk of muscle damage. This drug may interact with various medications, so patients taking other drugs must inform their doctor or pharmacist. In case of overdose, as there is no specific antidote, appropriate treatment and supportive therapy should be administered according to symptoms, and liver function and muscle damage should be monitored. Safety and efficacy in children have not been established, so use in this population is not recommended.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mouth/eyes mucous membranes, shortness of breath or difficulty breathing, asthma attacks, respiratory irregularities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and very severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination

Mild side effects

• Muscle pain
• abdominal pain
• elevated liver enzymes
• dizziness
• cough
• nausea
• joint pain
• muscle weakness
• musculoskeletal pain
• hyperkalemia

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is also important to store it at room temperature, between 1 to 30 degrees Celsius, to maintain the efficacy of the drug.

Appearance

White, rectangular, film-coated tablet

Package unit

PTP packaging - 30 tablets/box [10 tablets/PTP packaging (Alu-Alu) x3], bottle packaging - 30 tablets/bottle, bottle packaging - 100 tablets/bottle