Sinubide 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

For monotherapy or combination therapy, the usual dosage is 100 mg once daily, with a maximum daily dose of 100 mg. For patients with renal impairment, in cases of moderate renal impairment (glomerular filtration rate [eGFR] 30-45 mL/min/1.73 m2), the dosage is 50 mg once daily. In cases of severe renal impairment (glomerular filtration rate [eGFR]

This medication may rarely cause severe allergic reactions; thus, if symptoms such as skin rash or difficulty breathing occur, discontinue use immediately and seek medical attention. Pancreatitis may occur during medication use, so if symptoms such as sudden abdominal pain, vomiting, or nausea appear, visit a hospital immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, nor should those with allergies to this medication or its components. Patients with impaired kidney function need to adjust the dosage, therefore regular kidney function tests and adherence to doctor's instructions are necessary. During medication use, symptoms similar to a cold, headaches, dyspepsia, diarrhea, etc., may occur, and symptoms of hypoglycemia may also appear, making it important to monitor blood glucose frequently. Especially when taken together with other hypoglycemic agents like insulin or sulfonylureas, the risk of hypoglycemia is increased, so dosage adjustments should be discussed with a doctor if these medications are in use. If severe joint pain or skin blistering appears, inform a doctor immediately, and if necessary, discontinue medication. Use during pregnancy or breastfeeding is not recommended, so consult with a doctor before taking. Elderly patients may experience reduced kidney function; thus, kidney function should be periodically checked before and during medication use, and dosage adjustments may be needed. In the case of overdose, visit a hospital immediately for appropriate treatment since this medication can be partially removed by hemodialysis, which may be helpful if necessary. Co-administration with other medications has a low potential for drug interactions; however, caution is needed when taken with cyclosporine or digoxin due to possible changes in blood concentration.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, Stevens-Johnson syndrome, severe rash, blisters, skin peeling, oral/ocular mucosal pain, acute pancreatitis, liver dysfunction (elevated liver enzyme levels, signs of jaundice), acute kidney failure, severe edema, edema accompanied by increased blood pressure, severe and debilitating joint pain, bullous pemphigoid, rhabdomyolysis, severe allergic reaction, severe

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly closed container to prevent air or moisture from entering, and is best kept at room temperature between 1 and 30 degrees Celsius. Proper storage conditions will help maintain the medication's effectiveness.

Appearance

Light yellow pink round biconvex film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]