Sinubi Tablet 100 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This drug is administered once daily at a dose of 100 mg as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It can be taken without regard to meals. Dosage adjustment for patients with renal impairment: 1. For patients with mild renal impairment (eGFR ≥ 60 and < 90 mL/min/1.73 m2), dosage adjustment is not required. 2. For patients with moderate renal impairment (eGFR ≥ 45 and < 60 mL/min/1.73 m2), dosage adjustment is not required.

This drug may cause severe allergic reactions in some patients. If symptoms such as skin rash, difficulty breathing, or swelling of the face or neck appear within the first 3 months of starting the medication, use should be discontinued immediately and a physician consulted. Additionally, this drug can cause severe side effects such as pancreatitis, which is an inflammation of the pancreas. If abdominal pain, vomiting, or severe abdominal pain occurs, immediate medical attention is required. Patients with type 1 diabetes, diabetic ketoacidosis, or known allergies to this drug or its components should not use it. Patients with impaired kidney function may require dosage adjustments, and regular kidney function tests are important. During treatment, symptoms similar to a cold, headache, indigestion, or diarrhea may occur. When used in conjunction with insulin or other glucose-lowering agents for diabetes treatment, there is a risk of hypoglycemia, so careful monitoring of blood sugar is essential. If severe joint pain or blistering on the skin occurs, immediate consultation with a doctor is necessary, and discontinuation of the drug may be required if these symptoms are suspected. It is not recommended for use during pregnancy or breastfeeding. In case of overdose, standard treatment should be rendered, and dialysis may be necessary as needed. Finally, regular medical checkups to monitor for side effects during the use of this drug are important.

Serious side effects

Hives, angioedema, anaphylaxis, Stevens-Johnson syndrome, exfoliative skin disease, fatal hemorrhagic or necrotizing pancreatitis, acute pancreatitis, acute renal failure, severe joint pain with disabilities, bullous pemphigoid, pneumonia, diabetes complications, metabolic acidosis, falls, cardiac arrest

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• muscle pain
• limb pain

This drug should be stored in an airtight container and kept at room temperature (between 1 to 30 degrees Celsius). Proper storage will help maintain the drug's effectiveness over time.

Appearance

Light orange, round, biconvex film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]