Sitagliptin Tablets 25 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

In monotherapy or combination therapy, the recommended dose is 100 mg once daily, with a maximum daily dose of 100 mg. This medication can be taken regardless of meals. For patients with renal impairment, dosage adjustment may be necessary, depending on renal function. - For mild renal impairment (eGFR ≥ 60 and < 90), no dosage adjustment is needed. - For moderate renal impairment (eGFR ≥ 45 and < 60), dosage adjustment is needed.

This medication may cause severe allergic reactions in some patients; therefore, if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur after administration, use should be discontinued immediately and a physician should be consulted. If symptoms of pancreatitis such as severe abdominal pain, vomiting, or fever occur during treatment, medical personnel should be notified immediately, and drug therapy should be stopped if pancreatitis is suspected. This drug should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in patients who have had an allergic reaction to this drug or its components. For patients with decreased renal function, drug concentration may increase, so dosage should be adjusted according to renal function test results and used with caution. Hypoglycemic symptoms may occur during treatment, especially when used in combination with insulin or sulfonylureas, thus blood sugar should be frequently monitored and immediate action taken if symptoms appear. Rarely, severe joint pain or skin blistering symptoms have been reported; if these symptoms arise, the physician should be informed immediately, and discontinuation of the medication and specialist consultation may be necessary. Women who are pregnant or breastfeeding are advised against using this medication due to unestablished safety, and safety and efficacy have not been confirmed for children under 18. For elderly patients, dosage adjustment and regular renal function testing are needed due to potential decreases in renal function. In case of overdose, general first aid measures should be performed, and some drugs may be eliminated by hemodialysis if necessary. This medication does not have significant interactions with some other drugs; however, monitoring is needed for patients taking digoxin. Lastly, it is important to consult medical personnel immediately if any unusual symptoms or discomfort occur while taking this medication.

Serious side effects

Urticaria, angioedema, anaphylaxis, exfoliative skin disease (including Stevens-Johnson syndrome), acute pancreatitis, acute renal failure, severe joint pain with disability, bullous pemphigoid, pneumonia, diabetic complications, metabolic acidosis, falls, cardiac arrest

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• constipation
• vomiting
• myalgia
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly closed container to keep out air and should be kept at a temperature between 1 to 30 degrees Celsius at room temperature. This helps maintain the efficacy of the medication and prevent degradation.

Appearance

Pink, round, biconvex film-coated tablets

Package unit

30 tablets/box [10 tablets/PTP x 3]