Rinac Duo Tablet 2.5/500 mg

Adult dose

The dosage of this medication should not exceed the maximum recommended dosages of linagliptin 2.5 mg and metformin 1000 mg, administered twice daily, considering each patient’s current therapeutic regimen, efficacy, and tolerability. This medication should be taken twice daily with meals. 1. If currently not receiving treatment with metformin: Administer the initial dose of this medication 2.5/500 mg, 1 tablet twice daily.

This medication consists of two ingredients: metformin and linagliptin, and is primarily used for the treatment of type 2 diabetes. This medication should not be used in patients with impaired renal function or those with lactic acidosis, diabetic ketoacidosis, or type 1 diabetes. Additionally, it should be avoided in cases of severe hepatic impairment or acute diseases that may affect renal function, including acute infections, dehydration, severe trauma, shock, acute myocardial infarction. It is also advisable not to administer this medication to pregnant or nursing women, nor to those with hypersensitivity. This medication may cause hypoglycemic symptoms; therefore, special attention should be paid to these symptoms when taking it in combination with sulfonylureas or insulin. A rare side effect called lactic acidosis may occur, which can worsen due to sudden deterioration of renal function, cardiopulmonary diseases, or sepsis; in such cases, you should stop taking the medication immediately and seek medical attention. Regular assessment of renal function should be conducted before and during treatment, especially in elderly patients or those with impaired renal function. Skin allergic reactions, such as acute pancreatitis and bullous pemphigoid, have also been reported, so immediate medical consultation is necessary if severe abdominal pain or skin blisters arise. This medication can reduce vitamin B12 levels, so it is important to check for vitamin B12 deficiency during long-term treatment and consider supplementation if necessary. Additionally, potential interactions with other medications should be discussed, particularly with medications that may affect renal function. During surgeries or radiological tests, this medication should be temporarily discontinued and resumed only after renal function has recovered post-surgery. Elderly patients are more prone to renal function decline, so it is advisable to start with the minimum dose and regularly monitor renal function. This medication has not been established for safety and efficacy in children and should not be used in this population. In cases of overdose, there is a risk of lactic acidosis, necessitating immediate medical treatment, and blood dialysis may be required. When storing this medication, keep it out of reach of children, protect it from moisture, and store it in its original container.

Serious side effects

Hives, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, hepatic dysfunction (abnormal liver function tests, hepatitis), dyspnea, asthma attack, acute renal injury, acute myocardial infarction, severe allergic reactions, severe edema, angina pectoris, unstable angina, cardiac arrest, kidney transplant failure, acute cholangitis, acute cholecystitis, cholangitis, acute pyelonephritis, sepsis, severe myasthenia gravis, consciousness disturbance, vision changes, paralysis, lightning headache.

Mild side effects

• Nasopharyngitis
• taste disorder
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting
• abdominal pain
• oral ulcer formation

This medication should be stored in a tightly closed container to protect it from air and moisture. A temperature range of 1 to 30 degrees Celsius is recommended for room temperature storage. Proper storage will help maintain the medication's effectiveness for an extended period.

Appearance

Bright yellow oval film-coated tablet

Package unit

60 tablets/box [10 tablets/PTP×6]