Medication info

Canderova Tablet 20/32 mg

Prescription medicationTablet경구
Ingredient · strength
Rosuvastatin Calcium›20.8mg / 1 tabletCandesartan Cilexetil›32mg / 1 tablet
Manufacturer / importer
(주)경보제약
Appearance
Pink round film-coated tablet
Packaging
30 tablets (10 tablets/PTP X 3) - 30 tablets/PTP [30 tablets (10 tablets/PTP X 3)]
Approval status
Active

MFDS item code 202008713 · Approved 2020.12.11

Summary

Main use
(Hypertension, Heart Failure) Improvement and (Hypercholesterolemia, Cardiovascular Disease Risk) Reduction Effect
Who takes it
Adults · Children
Adult dose
Candesartan Cilexetil 1. Essential Hypertension - The recommended initial and maintenance dose is 8 to 16 mg orally once daily. If insufficient control is observed after 4 weeks of treatment at 16 mg, the dose may be increased up to 32 mg once daily. In patients with reduced intravascular effective blood volume: initiate with 4 mg. In patients with renal dysfunction: initiate with 4 mg and adjust based on patient response. In patients with liver dysfunction: initiate with 2 mg once daily. 2. Heart Failure - The initial dose is recommended as 4 mg once daily. After an interval of more than 2 weeks, doses may be doubled based on patient tolerance up to a maximum of 32 mg once daily. If the patient is elderly, with reduced intravascular effective blood volume, renal dysfunction, or mild to moderate liver dysfunction, dose adjustment is not necessary.
Child dose
The safety and efficacy in individuals under 18 years of age have not been established.

Ingredients

Manufacturer
(주)경보제약

Efficacy & effects

(Hypertension, Heart Failure) Improvement and (Hypercholesterolemia, Cardiovascular Disease Risk) Reduction Effect

  • Essential hypertension
  • heart failure
  • impaired left ventricular systolic function
  • hypercholesterolemia
  • heterozygous familial hypercholesterolemia
  • combined hyperlipidemia
  • homozygous familial hypercholesterolemia
  • dysbeta-lipoproteinemia
  • increased high-sensitivity C-reactive protein
  • hypertension
  • low HDL-cholesterol levels
  • smoking
View approved original text

This medication is used in patients who require the combined administration of the two components, Candesartan Cilexetil and Rosuvastatin. Candesartan Cilexetil is mainly used for patients with essential hypertension and heart failure, particularly effective in those with impaired left ventricular systolic function who have not responded adequately to ACE inhibitors or have poor tolerance. Rosuvastatin is used in patients with hypercholesterolemia and dyslipidemia in conjunction with dietary and exercise therapy or as an adjunct, reducing blood cholesterol levels and delaying the progression of atherosclerosis. It also helps to reduce the risk of stroke, myocardial infarction, and arterial revascularization in patients at high risk of cardiovascular disease. Thus, the combined administration of the two drugs is used to effectively manage hypertension and dyslipidemia, reducing the risk of cardiovascular disease.

How to take

Adult dose

Candesartan Cilexetil 1. Essential Hypertension - The recommended initial and maintenance dose is 8 to 16 mg orally once daily. If insufficient control is observed after 4 weeks of treatment at 16 mg, the dose may be increased up to 32 mg once daily. In patients with reduced intravascular effective blood volume: initiate with 4 mg. In patients with renal dysfunction: initiate with 4 mg and adjust based on patient response. In patients with liver dysfunction: initiate with 2 mg once daily. 2. Heart Failure - The initial dose is recommended as 4 mg once daily. After an interval of more than 2 weeks, doses may be doubled based on patient tolerance up to a maximum of 32 mg once daily. If the patient is elderly, with reduced intravascular effective blood volume, renal dysfunction, or mild to moderate liver dysfunction, dose adjustment is not necessary.

Child dose

The safety and efficacy in individuals under 18 years of age have not been established.

Precautions

This medication may cause serious harm to the fetus if taken during pregnancy, especially in the second and third trimesters, and should be discontinued immediately upon confirmation of pregnancy. This medication is contraindicated in patients with a known allergy to it, those with severe liver function impairment, and those with certain genetic lactase metabolism disorders. Special caution should be taken in elderly patients, those with impaired kidney function, and those with hyperkalemia, and regular blood tests and liver function tests should be performed under a doctor's advice. If symptoms such as myalgia or muscle weakness occur, immediate consultation with a physician is necessary, and in severe cases, it may be required to discontinue the medication. Interactions may occur if taken with other antihypertensive medications or certain lipid-lowering drugs; therefore, it is essential to inform the doctor or pharmacist of any other medications being taken. Caution is warranted as dizziness or fatigue may occur when driving or operating machinery. Women who could become pregnant should use appropriate contraception before taking this medication, and breastfeeding women are advised to avoid it. In cases of overdose, seek medical attention immediately, and since there is no specific antidote, treatment will be symptomatic. The safety and efficacy of this medication in children have not been established, thus it is not recommended. Keep the medication out of reach of children and do not transfer it from its original container to another.

Side effects and when to seek care immediately

Serious side effects

Hives, angioedema (face, lips, tongue, throat, etc.), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in the oral/ocular mucosa, difficulty breathing or shortness of breath, asthma attacks, respiratory difficulties accompanied by cough and fever, jaundice (yellowing of the skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness

Mild side effects

  • Headache
  • dizziness
  • nasopharyngitis
  • itching
  • dermatitis
  • nausea
  • dyspepsia
  • fatigue
  • myalgia
  • arthralgia
Show 28 more
  • increased blood sugar
  • decreased serum sodium
  • cough
  • increased blood pressure
  • hypoglycemia
  • nephrolithiasis
  • photophobia
  • tooth extraction
  • sore throat
  • limb pain
  • cataract
  • generalized itching
  • inflammation
  • foreign body sensation
  • chalazion
  • periodontitis
  • edema
  • asthenia
  • fatigue
  • thirst
  • loss of appetite
  • abdominal bloating
  • fainting
  • sensory abnormalities
  • chest discomfort
  • generalized pain
  • muscle cramps
  • pain

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly closed container to protect it from air and moisture. It is recommended to maintain the storage temperature between 1 degree and 30 degrees Celsius.

Appearance and packaging

Appearance

Pink round film-coated tablet

Package unit

30 tablets (10 tablets/PTP X 3) - 30 tablets/PTP [30 tablets (10 tablets/PTP X 3)]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.