Dapa Tablet 5mg (Dapagliflozin Citrate)

Adult dose

The recommended dose of this medication is 10mg once daily for monotherapy and additional combination therapy. In initial combination therapy, the dose is 5mg or 10mg once daily. For patients with chronic heart failure and chronic kidney disease, the dose is 10mg once daily. This medication can be taken orally at any time of the day, regardless of food intake. The tablet should be swallowed whole.

Child dose

The efficacy and safety of dapagliflozin in children under 18 years of age have not been established. There is no relevant data.

This medication should not be used in patients with allergies to its active ingredients or excipients, type 1 diabetes mellitus, patients with diabetic ketoacidosis, patients with genetic issues such as lactose intolerance or glucose-galactose malabsorption, and patients on dialysis. It should be administered with caution in patients with volume depletion or impaired kidney function. This medication may cause a decrease in blood pressure or abrupt changes in kidney function, so fluid status and kidney function should be carefully monitored and observed before and during administration. The most common side effect while taking this medication is genital infection. Other reported side effects include urinary tract infection, hypoglycemia, volume depletion, dizziness, dry mouth, constipation, and back pain. Hypoglycemia, especially, may occur more frequently if used with insulin or sulfonylureas, so caution is required. This medication may reduce the effectiveness of blood sugar control in patients with decreased kidney function and is not recommended for patients with very low kidney function. Women who are pregnant or breastfeeding are advised not to use this medication, and it should be discontinued immediately upon confirmation of pregnancy. Elderly patients are advised to be particularly cautious when taking this medication due to the higher risk of impaired kidney function and volume depletion. When used with other diuretics, this medication may increase the risk of dehydration and hypotension, so if taken together, careful observation of fluid status is necessary. Additionally, this medication has the action of increasing urination, which may worsen the condition in patients with bladder-related diseases, so caution is needed. Serious metabolic acidosis called ketoacidosis may occur during the use of this medication, so if symptoms such as vomiting, abdominal pain, difficulty breathing, or lethargy occur, immediate consultation with a healthcare professional is advised. This medication may affect the results of certain tests for blood sugar control, so it is advisable to discuss the testing methods with healthcare professionals. There are no specific antidotes for overdose, so appropriate treatment should be administered depending on symptoms while monitoring the patient's progress. Lastly, this medication is not recommended for use in children due to a lack of established safety and efficacy.

Serious side effects

• Severe swelling (edema)
• cold sweat
• hives
• diabetic ketoacidosis
• volume depletion
• low blood pressure
• acute kidney injury
• renal dysfunction
• perineal necrosis (Fournier's gangrene)
• urinary sepsis

Mild side effects

• Vulvovaginal candidiasis
• balanitis and related genital infections
• urinary tract infection
• fungal infection
• hypoglycemia
• dry mouth
• dizziness
• constipation
• dry mouth
• back pain

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain the storage temperature between 1°C and 30°C. Proper storage will help to maintain the effectiveness of the medication over time.

Appearance

Yellow, double-convex, round film-coated tablet

Package unit

28 tablets/box [(14 tablets/PTPX 2)]