Altinon Soft Capsule 10mg (Alitretinoin)

Adult dose

- Take 10~30mg once daily with or immediately after a meal. It is preferable to take it at the same time each day. - The initial dose is 30mg of alitretinoin; reduce to 10mg depending on adverse reactions. - Patients with diabetes, obesity, cardiovascular risk factors, or dyslipidemia: Administer an initial dose of 10mg and, if needed, increase to 30mg depending on tolerability and efficacy. Periodic monitoring of the blood lipid profile and blood glucose may be necessary during treatment with this drug. - Discontinue treatment as soon as the treatment goal of clear or almost clear hands is achieved. If hand eczema remains severe after the initial 12 weeks of treatment, discontinue treatment; also discontinue treatment if the treatment goal has not been achieved by 24 weeks of treatment.

This medication poses a very high risk of causing serious birth defects if taken during pregnancy; therefore, women who are pregnant or may become pregnant must not take it under any circumstances. During the treatment, effective contraception methods must be used for at least one month before and after treatment. Pregnancy tests should be conducted every month during treatment to confirm pregnancy status; if pregnancy is confirmed, the medication should be immediately discontinued, and medical consultation should be sought. High levels of triglycerides in the blood may lead to serious side effects, such as acute pancreatitis; thus, blood lipid levels should be regularly monitored, and treatment should be stopped if abnormalities are detected. This medication should not be administered to individuals with certain conditions, such as liver disease, severe kidney disease, or uncontrolled hypothyroidism. Patients with a history of mental illness should be carefully monitored for worsening psychiatric symptoms such as depression or mood changes before and after taking the medication. This medication may cause various side effects such as dry skin, headache, flushing, and changes in thyroid function; any unusual symptoms should be promptly discussed with healthcare professionals. Increased sensitivity to ultraviolet radiation occurs, so caution is needed to avoid excessive exposure to sunlight or artificial light sources, and the use of sunscreen is recommended. Exercise should avoid strenuous activities, and in case of dry eye symptoms, artificial tears or lubricating eye ointments may help. This medication should not be taken in combination with other retinoid products or vitamin A due to an increased risk of side effects. Additionally, concurrent use of the specific antibiotic tetracycline is contraindicated as it may cause serious side effects. During the use of this medication, strict adherence to the pregnancy prevention program is necessary, and it should never be shared with others. Excessive dosages may lead to severe headaches, diarrhea, and facial flushing; thus, the prescribed dose must be strictly followed, and in the case of men, sexual relations with women who may become pregnant should be avoided or condoms used for 30 days following overdose. This medication should be taken with food or immediately after a meal, and stored in a cool place out of reach of children, avoiding direct sunlight.

• Headache
• erythema
• flushing
• increased triglycerides
• increased cholesterol
• decreased thyroid-stimulating hormone
• decreased free T4
• anemia
• increased iron-binding capacity
• decreased monocytes

This medication is sensitive to light; therefore, it should be stored in a dark container that prevents light exposure. It is also important to store it at a cool temperature below 30 degrees Celsius to maintain its effectiveness.

Appearance

Brown oval soft gelatin capsule containing yellow oily contents

Package unit

30 capsules/PTP [10 capsules/PTP × 3]