Janugrine 50 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication is administered as 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Dosage adjustments for renal impairment: - Mild renal impairment (glomerular filtration rate [eGFR] 60-90 mL/min/1.73 m²): No dose adjustment necessary - Moderate renal impairment (glomerular filtration rate [eGFR] 45-60 mL/min/1.73 m²): No dose adjustment necessary

This medication may cause allergic reactions, so if symptoms such as skin rash or difficulty breathing occur within three months after initial use, discontinue immediately and consult a doctor. Serious inflammation of the pancreas known as pancreatitis may occur while taking this medication, so if symptoms like abdominal pain, vomiting, or fever arise, notify the healthcare professional immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not take this medication, nor should those who are allergic to this medication or its components. Patients with impaired kidney function may have delayed drug elimination, necessitating dosage adjustments and regular kidney function tests. Side effects may include upper respiratory infection, headache, rhinitis, dyspepsia, diarrhea, nausea, etc., and particularly when taken with insulin or sulfonylureas, there is an increased risk of hypoglycemia. In the event of hypoglycemic symptoms, blood sugar should be checked immediately and appropriate measures taken if necessary, and insulin or sulfonylurea doses may need adjustment to reduce the risk of hypoglycemia. This medication may cause serious skin conditions such as arthralgia or bullous pemphigoid, so consult a doctor immediately if such symptoms occur. Pregnant or breastfeeding women are advised against taking this medication, and safety has not been established for children or adolescents under 18 years of age. This medication generally has few drug interactions, but it is important to closely monitor blood concentration changes if taken with cyclosporine or digoxin. In cases of overdose, appropriate treatments such as gastrointestinal decontamination and electrocardiogram monitoring should be performed, with hemodialysis considered for removing some of the medication if necessary. Elderly patients may have increased likelihood of reduced kidney function, hence dosage adjustments and regular kidney function testing are necessary, and regular health evaluations during medication use are recommended.

Serious side effects

• Hives
• severe swelling (angioedema)
• anaphylaxis
• rash
• Stevens-Johnson syndrome
• vasculitis
• exfoliative skin disease
• acute pancreatitis
• elevated liver enzymes
• acute renal failure

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• myalgia
• limb pain

Store this medication in a tightly sealed container to prevent air ingress, and keep at room temperature between 1 to 30 degrees Celsius. This helps maintain the efficacy of the medication and prevents degradation.

Appearance

Light yellow-pink round biconvex film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP×3]