Siglebe Tablets 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg in both monotherapy and combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. For patients with renal impairment, dosage adjustment is needed based on kidney function. - Mild renal impairment (eGFR 60-90 mL/min/1.73 m²): No dosage adjustment necessary. - Moderate renal impairment (eGFR 45-60 mL/min/1.73 m²): No dosage adjustment necessary.

This medication may cause allergic reactions; therefore, if symptoms such as rash or difficulty breathing occur, stop taking the medication immediately and consult a doctor. This drug may cause serious pancreatic inflammation known as pancreatitis, so it is important to observe for abdominal pain, vomiting, or severe digestive symptoms during treatment and report them to medical personnel immediately. This drug is not recommended for patients with type 1 diabetes or diabetic ketoacidosis. Patients who have had allergic reactions to this drug or its components should not take it. Patients with impaired kidney function should adjust the dosage of this drug, and it is important to receive regular kidney function tests. During the course of taking this drug, mild side effects such as cold symptoms, headache, and digestive discomfort may occur; if symptoms are severe or persist, inform your doctor. When taken in conjunction with insulin or other hypoglycemic agents like sulfonylureas, the risk of hypoglycemia may increase, so blood sugar levels should be monitored frequently, and any symptoms should be promptly addressed. This drug is not recommended for pregnant or breastfeeding women, and its safety in children and adolescents under 18 years of age has not been established. Elderly patients may experience decreased kidney function, necessitating dosage adjustments and regular kidney function tests. In cases of overdose, appropriate medical action should be taken to remove the drug from the gastrointestinal tract and conduct an electrocardiogram; blood dialysis can help remove some of the drug. If symptoms such as joint pain or blisters on the skin occur during the course of taking this drug, consult a doctor immediately to determine whether to discontinue the medication. There are few significant interactions with other medications, but caution is needed when taking specific drugs, so inform your healthcare provider of all medications being taken.

Serious side effects

Hives, angioedema, anaphylaxis, acute pancreatitis, exfoliative skin diseases (including Stevens-Johnson syndrome), severe hypoglycemia, acute renal failure, severe and disabling joint pain, bullous pemphigoid, elevation of liver enzymes, liver abnormalities (potential for jaundice), pneumonia, diabetic complications, metabolic acidosis, falls, cardiac arrest

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container that is well-ventilated, and the storage temperature should be kept between 1 and 30 degrees Celsius room temperature. This will help maintain the drug's effectiveness over time.

Appearance

Light yellow pink, round, biconvex film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]