Cenex Capsule 400 mg (Celecoxib)

Adult dosage

* Celecoxib 400 mg formulation The minimum recommended dose of this medicine should be adjusted for each patient and may be administered with or without food. ○ Adults 1. Ankylosing spondylitis (AS) Administer celecoxib 200 mg once daily or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of treatment with 400 mg daily, another treatment method should be considered. 2. Acute pain and primary dysmenorrhea The recommended initial dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This drug can pose a risk of gastrointestinal bleeding if taken by individuals who regularly consume more than three glasses of alcohol per day, so it's essential to consult a doctor or pharmacist. It may increase the risk of cardiovascular disease, leading to serious cardiovascular issues such as myocardial infarction or stroke, so it should be used at the minimum effective dose and for the shortest duration possible. There is a risk of gastrointestinal perforation, ulcers, and bleeding, especially in the elderly or in those with a history of gastrointestinal diseases; extra caution is advised. This medication may cause certain allergic reactions, so individuals with a history of hypersensitivity should not take it. Patients with severely impaired liver or kidney function, those with active peptic ulcer disease or inflammatory bowel disease, and those with heart failure should not be administered this drug. Patients with mildly impaired liver or kidney function, hypertension, heart failure, or asthma should use this drug cautiously. Dizziness or drowsiness may occur during use, so caution is advised when driving or operating machinery. This drug may interact with several other medications, so individuals currently taking other drugs should inform their doctor or pharmacist, and dosage adjustments may be necessary. Women who are pregnant or breastfeeding should not take this medication, and women planning on becoming pregnant should exercise caution. Long-term use may require regular blood tests and liver and kidney function assessments, and if any abnormal symptoms arise, immediate consultation with medical personnel is necessary. In cases of overdose, symptoms may include lethargy, nausea, vomiting, and abdominal pain, necessitating immediate medical attention. This medication should not be used in children and adolescents as its safety and efficacy have not been established.

Gastrointestinal bleeding, cardiovascular thrombotic events, myocardial infarction, stroke, upper and lower gastrointestinal perforation, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, liver enzyme elevation, pruritus, rash, urticaria, petechiae, angioedema, alopecia, bullous dermatitis, peripheral edema, facial swelling, influenza-like illness, trauma, headache, leg cramps, sensory disturbance, migraine, neuralgia, neuropathy, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, allergic exacerbation, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, loss of appetite, increased appetite, depression, neuro-excitability, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory tract infection, bronchospasm, exacerbated bronchospasm, dyspnea, laryngitis, pneumonia, nosebleed, voice disorders, vesicular dermatitis, dermatitis, nail disease, photosensitivity reaction, pruritus, erythematous rash, maculopapular rash, skin diseases, skin dryness, increased sweating, erythema multiforme, exfoliative dermatitis, mucocutaneous syndrome, toxic epidermal necrolysis, eczema, lipoma, drug rash, arrhythmia, left ventricular hypertrophy, angina pectoris, unstable angina, coronary artery disease, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombotic venous inflammation, vasculitis, deep vein thrombosis, cerebral hemorrhage, varicella, wound infection, gingivitis, herpes simplex, shingles, bacterial infection, fungal infection, soft tissue infection, viral infection, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, auditory impairment, liver function abnormalities, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, elevated CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, elevated LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthritis, skeletal abnormalities, myalgia, cervical tension syndrome, synovitis, tendinitis, myositis, fractures, tendon rupture, pain in various areas, muscular rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleed, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, leukocytosis, contact dermatitis, injection site reaction, skin nodules, taste disorder, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, elevated serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute kidney injury, interstitial nephritis, anaphylactic reaction, hallucination, cerebral hemorrhage, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute kidney injury, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change glomerulonephritis, female infertility, chest pain, lethargy, drowsiness, nausea, vomiting, upper abdominal pain, gastrointestinal bleeding, hypertension, acute kidney injury, respiratory depression, coma

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius to preserve the drug's efficacy.

Appearance

A white capsule filled with a white to slightly yellow powder with green stripes on both ends.

Package unit

30 capsules/bottle, 100 capsules/bottle