Creszet Tablet 10/5 mg (Ezetimibe, Rosuvastatin)

Adult dose

This medication is taken once a day, regardless of meals. For primary hypercholesterolemia, it is administered in the range of 10/5mg to 10/20mg daily, with a recommended initial dose of 10/5mg. Patients requiring a larger reduction in LDL-cholesterol may adjust their dosage. After starting treatment or adjusting the dosage, lipid levels should be checked at intervals of at least 4 weeks to adjust the dosage as needed.

This medication can affect muscles and may result in muscle pain, muscle weakness, or in severe cases, rhabdomyolysis. Patients who experience serious muscle issues or who are at high risk for muscle damage due to acute infections, hypotension, major surgery, etc., should temporarily halt or discontinue use of this medication. Patients allergic to ingredients in this medication, those with active liver disease, patients with unexplained persistent liver enzyme elevations, those with muscle diseases, patients with severe kidney impairment, pregnant women or women who may become pregnant, and nursing mothers should not take this medication. Additionally, patients with kidney or liver problems, those with a history of alcoholism, hypothyroidism, elderly patients, or those with a history of certain genetic muscle disorders should use this medication with caution and consult a physician immediately if muscle-related symptoms develop. During the course of taking this medication, regular liver function tests and muscle enzyme tests should be performed, and patients should inform their healthcare providers immediately if muscle pain, muscle cramps, malaise, or fever occurs. If there are signs of worsening liver function or severe liver damage, medication should be discontinued. This medication can interact with other drugs, so patients must inform healthcare providers about current medications, especially when taking certain antibiotics, antifungals, immunosuppressives, anticoagulants, or fibrate class drugs, as caution is needed in these cases. Pregnant or nursing women should not take this medication, and women of childbearing age should use appropriate contraceptive methods during treatment. This medication has not been adequately evaluated for effectiveness or safety in children and adolescents, therefore it is not recommended. Elderly patients are at higher risk of myopathy, so caution is advised during use, and dizziness may occur when driving or operating machinery, so patients should be careful. In cases of overdose, since there is no specific antidote, appropriate treatment and supportive therapy based on symptoms are needed, including monitoring liver function and muscle enzyme levels. Lastly, this medication should be kept out of reach of children, and transferring it to another container could alter its quality, so caution is advised.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blistering, peeling skin, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attacks, breathing abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), severe lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

Headache, dizziness, dyspepsia, edema, muscle pain, dry mouth, increase in blood lactate dehydrogenase enzyme, pruritus, discomfort in the chest, elevated blood sugar, thrombocytopenia, dermatitis, skin burning sensation, alopecia, cough, arthralgia, osteoarthritis, osteoporosis, musculoskeletal stiffness, musculoskeletal discomfort, muscle weakness, skin itching, rash, hyperhidrosis, upper respiratory tract infections, conjunctival hyperemia, nausea, diarrhea, constipation, loss of appetite, abdominal bloating, fatigue,

This medication should be stored in a tightly closed container to protect it from air and moisture, and it is recommended to keep it at room temperature between 1 to 30 degrees Celsius. This storage method helps maintain the drug's effectiveness and safety.

Appearance

Pink elongated film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP×3]