Rosuvastatin/Ezetimibe Combination 10/20 mg

Adult dose

This drug is administered once daily regardless of meals. For primary hypercholesterolemia, a starting dose of 10/5 mg once daily is recommended. In patients requiring greater reduction of LDL cholesterol, adjustments to the dosage can be made. After appropriate dosing, the serum lipid levels should be checked at intervals of at least four weeks, and dosing can be adjusted accordingly, up to a maximum of 10/20 mg once daily.

This drug has been reported to cause a rare side effect called rhabdomyolysis, which can result in serious muscle damage. Therefore, if severe muscle pain or weakness occurs, it is important to consult a doctor immediately. This drug should not be used in patients with impaired liver function or patients with active liver disease. Patients with severely reduced kidney function, those with muscular diseases, women who are pregnant or may become pregnant, and nursing mothers should not take this drug. In cases with a high risk of myopathy, such as alcoholics or patients with a history of liver disease, the elderly, and patients with hypothyroidism, this drug should be used with caution and regular testing is required. This drug can interact with other medications; therefore, if other drugs are currently being taken, it is crucial to inform the doctor or pharmacist. Special caution is needed when used in conjunction with anticoagulants, certain antibiotics, or medications that affect liver function. While taking this drug, regular liver function tests and muscle-related tests should be carried out, and any unusual symptoms should be reported to healthcare professionals immediately. Use of this drug is contraindicated during pregnancy and breastfeeding due to risks to the fetus and newborn, and women of childbearing potential should use appropriate contraception. Safety in children or adolescents has not been sufficiently established; therefore, it is not recommended for pediatric use. In case of overdose, there is no specific antidote available, and appropriate treatment should be taken according to symptoms, monitoring liver and muscle function tests.

Serious side effects

Allergic reactions including urticaria, angioedema, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms, acute renal failure, thrombocytopenia, jaundice, hepatitis, toxic hepatitis, acute hepatitis, renal impairment, renal failure, chest pain, breathing difficulties, difficulty in breathing, chest tightness, seizure, severe edema, severe allergic reactions, severe skin reactions, severe neurological symptoms, high fever accompanied by

Mild side effects

• Headache
• dizziness
• dyspepsia
• ALT elevation
• AST elevation
• edema
• myalgia
• dry mouth
• abnormal liver function tests
• increased serum lactate dehydrogenase

This drug should be stored in a tightly closed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature. Storing it this way can help retain the drug's efficacy for a longer duration.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3], 30 tablets/bottle, 100 tablets/bottle