Sitagliptin 50 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with renal impairment, dosage adjustment is necessary based on kidney function. - Mild renal impairment (eGFR 60 to < 90): No dosage adjustment required. - Moderate renal impairment (eGFR 45 to < 60): No dosage adjustment required. - Moderate renal impairment

This medication may rarely cause severe allergic reactions after administration; therefore, if symptoms such as rash, difficulty breathing, swelling of the face or tongue occur, usage should be discontinued immediately and consultation with a physician should be sought. This medication may induce serious inflammation of the pancreas (pancreatitis); if symptoms such as abdominal pain, vomiting, or loss of appetite appear, immediate medical attention is required. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should not be administered if there is an allergy to this medication or its components. Patients with impaired kidney function may have delayed excretion of this medication, necessitating dosage adjustments and regular monitoring of kidney function. The risk of hypoglycemia may increase when used with other hypoglycemic agents, especially insulin or sulfonylureas; thus, attention to hypoglycemia symptoms and dosage adjustments of other medications may be needed. If severe joint pain or blistering skin conditions occur during treatment, immediate consultation with a physician is recommended and consideration for discontinuing the medication may be warranted. This medication is not recommended for use during pregnancy, and nursing mothers should also avoid taking it. Safety and efficacy in children and adolescents have not been established; therefore, it is preferable not to use it in these populations. Elderly patients are at higher risk for impaired renal function, so periodic assessment of kidney function before and during treatment is recommended. In case of overdose, general symptomatic treatment should be undertaken, and consideration may be given to blood dialysis for drug removal if necessary. This medication has fewer interactions with other drugs, but caution is advised when used with digoxin or cyclosporine, and medical guidance should be followed.

Serious side effects

• Urticaria
• angioedema
• anaphylaxis
• Stevens-Johnson syndrome
• acute pancreatitis
• acute kidney injury
• severe hypoglycemia
• severe joint pain with disability
• blistering pemphigoid
• pneumonia

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• diarrhea
• abdominal pain
• nausea
• constipation
• vomiting
• myalgia
• limb pain

This medication should be stored in a tightly sealed container to prevent air ingress. It is recommended to store at room temperature between 1°C and 30°C to maintain the effectiveness of the drug for a longer duration.

Appearance

Pale yellowish pink round biconvex film-coated tablet

Package unit

28 tablets) 14 tablets/PTP(x2), 30 tablets) 10 tablets/PTP(x3)