Halim Sitagliptin 50 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The recommended dose for this medication is 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken with or without meals. For patients with renal impairment, dose adjustments are necessary based on kidney function. - No dose adjustment is needed for mild renal impairment (eGFR 60-90 mL/min/1.73 m2). - For moderate renal impairment (eGFR 45-60 mL/min/1.73 m2)...

This medication may cause severe allergic reactions, so if skin rash, difficulty breathing, swelling of the face or neck occurs after use, discontinue immediately and consult a doctor. Additionally, cases of acute pancreatitis, which is inflammation of the pancreas, have been reported; if abdominal pain, nausea, or vomiting occurs during use, seek medical attention immediately. Should not be administered to patients with type 1 diabetes or diabetic ketoacidosis, and should also be avoided in cases of allergy to this drug or its ingredients. Patients with decreased renal function may have difficulty excreting the drug, requiring dose adjustment and careful monitoring based on renal function. Hypoglycemic symptoms may occur during use of this medication, especially when taken with insulin or sulfonylureas; blood glucose levels should be monitored carefully and dosage adjusted if necessary. Severe joint pain or blistering skin conditions may occur; inform the doctor immediately if these symptoms arise. Use of this medication is not recommended for pregnant or nursing women, and safety in children under 18 has not been established. Elderly patients may have reduced renal function, thus requiring dose adjustment and regular kidney function testing. In case of overdose, general emergency treatment should be carried out, and it may be considered that blood dialysis can partially remove the drug if necessary. Caution should be exercised with drug interactions when used with other hypoglycemic agents, and dose adjustment may not be necessary for certain medications due to minimal pharmacokinetic changes.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, severe skin reactions (Stevens-Johnson syndrome, exfoliative skin diseases), acute pancreatitis (hemorrhagic or necrotizing pancreatitis, fatal/non-fatal), acute renal failure, liver abnormalities (including elevated liver enzymes), severe joint pain with disability, bullous pemphigoid, cardiac arrest, pneumonia, severe edema with hypertension, thrombocytopenia

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

This medication should be stored in a tightly sealed container to prevent air exposure, ideally kept at room temperature between 1°C and 30°C. Storing it this way helps maintain the drug's effectiveness and prevents degradation.

Appearance

Pale yellow pink round biconvex film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP × 3]