Janurodi Tablet 25 mg (Sitagliptin hydrochloride hydrate)

Adult dose

The typical dose is 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. This medication can be taken without regard to meals. Dosage adjustment is necessary based on kidney function. Moderate and mild renal impairment patients (eGFR 45 to less than 90) do not require dose adjustment. For moderate renal impairment (eGFR 30 to less than 45), the dosage is once daily at 50 mg.

This medication may rarely cause serious allergic reactions; if you experience symptoms such as skin rash, difficulty breathing, or swelling of the face or neck after taking the medication, you should immediately stop taking it and consult a physician. This medication may cause serious side effects such as pancreatitis, which is inflammation of the pancreas; if you experience abdominal pain, vomiting, or nausea during treatment, you should seek medical attention immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should be avoided in individuals with known allergies to the drug or its components. Patients with impaired kidney function should have their dosage adjusted and should regularly undergo kidney function checks while taking this medication. The risk of hypoglycemia may increase if this medication is taken with other glucose-lowering agents, especially insulin or sulfonylureas; therefore, careful monitoring of blood glucose levels is advised. If symptoms such as joint pain or skin blistering occur during treatment, you should immediately inform your doctor and discontinue the medication. It is recommended that women who are pregnant or breastfeeding do not take this medication, and its safety and efficacy have not been established in children or adolescents under 18 years of age. Elderly patients may have decreased kidney function; therefore, caution is required when taking this medication, and regular kidney function testing is advisable. In case of overdose, you should seek medical attention immediately, and in some cases, hemodialysis may be necessary. This medication has a low potential for interactions with other drugs, but it is advisable to consult with a physician or pharmacist if certain medications are being taken.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, exfoliative skin conditions (including Stevens-Johnson syndrome), acute pancreatitis, acute renal failure, severe and disabling arthralgia, blistering dermatitis, elevated liver enzymes, rhabdomyolysis, pneumonia, diabetic complications, metabolic acidosis, falls, cardiac arrest

Mild side effects

• Upper respiratory tract infections
• nasopharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• muscle pain
• limb pain

Store this medication in a tightly sealed container to prevent air exposure, at a temperature between 1 and 30 degrees Celsius. Storing in this manner helps maintain the efficacy of the medication for a longer period.

Appearance

Pink, round, double-convex, film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3)