Janugliflozin 25 mg Tablet (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Dose adjustments for patients with renal impairment: - Mild to moderate renal impairment (eGFR 45 or greater but less than 90): Dose adjustment not needed - Moderate renal impairment (eGFR 30 or greater but less than 45): 50 mg once daily - Severe

This medicine can rarely cause severe allergic reactions; therefore, if symptoms such as skin rash or difficulty breathing occur, its use should be stopped immediately and medical consultation sought. Additionally, acute pancreatitis, which involves inflammation of the pancreas, may occur, so if abdominal pain, vomiting, or severe abdominal discomfort is felt, immediate medical attention is necessary. This drug should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in patients allergic to any of the drug components. Patients with reduced kidney function may experience a slower excretion of the medication, requiring dose adjustments or cautious use, along with regular kidney function tests. When used with other diabetes medications or insulin that can cause hypoglycemia, close attention to hypoglycemic symptoms is advised, and dose adjustments of other medications may be necessary. During the use of this drug, symptoms such as headache, upper respiratory infection, pharyngitis, diarrhea, and nausea may occur, and if they are severe or persistent, medical consultation should be sought. The safety of this drug has not been established in pregnant or nursing women, and its use is not recommended in children or adolescents under 18 years of age. In the elderly, dose adjustments and kidney function monitoring are necessary as kidney function may decline. In case of overdose, immediate medical attention is necessary to receive appropriate treatment, and some medications can be removed via hemodialysis. This drug has relatively few interactions with other medications, but caution is required when taking certain medications, thus it is important to inform healthcare providers about all medications being taken. If severe joint pain or skin blistering occurs during treatment, discontinue the drug and seek evaluation from a specialist.

Serious side effects

Severe hypersensitivity reactions (including anaphylaxis, angioedema, Steven-Johnson syndrome, and exfoliative skin diseases), acute pancreatitis (including hemorrhagic or necrotizing), severe hypoglycemia, acute kidney failure (sometimes requiring dialysis), severe joint pain with disability, bullous pemphigoid, increased liver enzymes, liver abnormalities (including jaundice), pneumonia, diabetes complications, metabolic acidosis, falls, cardiac arrest, rhabdomyolysis, serious skin adverse reactions, severe

Mild side effects

• Upper respiratory infection
• pharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• myalgia
• limb pain

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is best to keep it at room temperature between 1°C and 30°C. Proper storage will help maintain the drug's effectiveness for a longer period.

Appearance

Light orange, round, biconvex, film-coated tablet

Package unit

28 tablets/PtP [14 tablets/PtP * 2]