Januglutide Tablet 100 Milligrams (Sitagliptin Hydrochloride Hydrate)

Adult dose

The recommended adult dosage for this medication is 100 mg of sitagliptin administered once daily either as monotherapy or in combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. Patients with renal impairment may require dosage adjustments based on renal function. In patients with mild to moderate renal impairment, dosage adjustments are not necessary. For patients with a glomerular filtration rate of 30-45 mL/min/1.73 m², the dosage is 50 mg once daily.

This medication may cause allergic reactions; therefore, if symptoms such as skin rash or difficulty in breathing occur, it should be discontinued immediately, and a doctor consulted. If symptoms of acute pancreatitis, such as severe abdominal pain, vomiting, or fever, occur during the course of taking this medication, medical personnel should be notified immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Patients with impaired kidney function may need dosage adjustment for this medication, so regular kidney function tests should be conducted. This medication may increase the risk of hypoglycemia when taken with other blood glucose-lowering agents, particularly insulin or sulfonylureas, so caution is advised, and dose adjustments of other medications may be necessary if needed. If symptoms of severe joint pain or skin blistering occur, the medication should be stopped immediately, and a doctor consulted. Pregnant or breastfeeding women are advised to avoid using this medication. This medication may also be used in the elderly, but dosage adjustments should be made considering decreased kidney function, and regular check-ups are necessary. In cases of overdose, general emergency procedures should be followed, and blood dialysis may be done if necessary. Some patients may experience side effects such as dyspepsia, headache, upper respiratory tract infection, so if abnormal symptoms persist, they should inform medical personnel.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe skin reactions (Stevens-Johnson syndrome, rash, vasculitis, exfoliative dermatitis), acute pancreatitis, liver abnormalities (elevated liver enzymes, potential jaundice), acute kidney failure, severe joint pain accompanied by disabilities, bullous pemphigoid, rhabdomyolysis, cardiac arrest, pneumonia, diabetes complications, metabolic acidosis, severe hypoglycemia, severe neurological symptoms (seizures, alteration of consciousness)

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• diarrhea
• abdominal pain
• nausea
• constipation
• muscle pain
• limb pain
• back pain

This medication should be stored in a tightly sealed container that is well-ventilated, and kept in an environment maintaining room temperature between 1°C and 30°C. Proper storage helps maintain the effectiveness and safety of the medication.

Appearance

Light orange, round, bilayer concave film-coated tablet

Package unit

28 Tablets/PVC [14 Tablets/PVC * 2]