Anivia Tablet 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dosage of 100 mg, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with renal impairment, dosage adjustments should be made according to renal function as follows: - Mild renal impairment (eGFR 60 to less than 90): no dosage adjustment needed. - Moderate renal impairment (eGFR 45 to less than 60): no dosage adjustment needed. - Moderate renal impairment (eGFR 30 to less than 45): administer 50 mg once daily. - Severe renal impairment (eGFR 15 to less than 30) or in patients requiring hemodialysis or peritoneal dialysis (ESRD) (eGFR less than 15): administer 25 mg once daily. This medication can be taken regardless of dialysis timing.

This medication may cause severe allergic reactions, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur, discontinue use immediately and consult a healthcare provider. This medication may cause serious pancreatic inflammation known as pancreatitis; if symptoms such as abdominal pain, vomiting, or loss of appetite occur while taking it, inform a doctor immediately. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Patients with impaired renal function may need dosage adjustments, and regular renal function tests are important. Cold symptoms, headaches, and upper respiratory infections may occur during treatment, so consult with a healthcare provider if symptoms persist. There is an increased risk of hypoglycemia when used with other blood glucose-lowering medications or insulin; therefore, check blood sugar levels frequently and adjust dosage if necessary. If severe joint pain or skin blisters occur, discontinue this medication and consult a doctor. Pregnant or breastfeeding women are advised to avoid using this medication, and safety in children and adolescents under 18 has not been established. If an overdose occurs, seek proper treatment at a hospital immediately, and it can be partially removed by hemodialysis. This medication does not significantly increase the risk of major cardiovascular issues, but regular health check-ups are necessary during treatment.

Serious side effects

Severe hypersensitivity reactions (anaphylaxis, angioedema, urticaria), severe skin adverse reactions (Stevens-Johnson syndrome, exfoliative dermatitis), acute pancreatitis, acute renal failure, severe edema, bullous pemphigoid, severe and disabling arthralgia, rhabdomyolysis, pneumonia, diabetes complications, metabolic acidosis, cardiac arrest

Mild side effects

• Hypoglycemia
• upper respiratory infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• muscle pain

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, ideally at room temperature between 1 and 30 degrees Celsius. This helps maintain the medication's effectiveness and prevents degradation.

Appearance

Light orange, round, biconvex, film-coated tablet

Package unit

28 tablets) 14 tablets/PPT (x2), 30 tablets) 10 tablets/PPT (x3)