Janudau Tablet 50 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The recommended dosage is 100 mg once daily, either as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with kidney impairment, dosage adjustments may not be necessary for mild and moderate kidney impairment (eGFR 45 or greater but less than 90). In moderate kidney impairment with an eGFR of 30 to less than 45, give 50 mg once daily.

This medication may rarely cause serious allergic reactions; therefore, if symptoms such as rash or difficulty breathing occur within 3 months of starting therapy, it should be discontinued immediately and a physician consulted. This medication can induce a serious inflammation of the pancreas known as pancreatitis; thus, if symptoms such as abdominal pain, vomiting, or loss of appetite arise during therapy, medical personnel should be informed immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis and should not be used if there is hypersensitivity to this medication or any of its components. Patients with impaired kidney function may need dosage adjustments for this medication, so regular kidney function tests should be performed per the physician's directions. There is a risk of hypoglycemia during the use of this medication, so blood glucose should be carefully monitored, particularly when used in conjunction with insulin or sulfonylureas. If severe joint pain or blistering of the skin occurs, it is necessary to inform a physician immediately and discontinue the medication. This medication is not recommended for use in pregnant or breastfeeding women, and safety and effectiveness have not been established for children and adolescents under 18 years of age. Elderly patients may have decreased kidney function; thus, dosage adjustment and regular assessments of kidney function are important. In case of overdose, emergency measures such as removal of the drug from the gastrointestinal tract may be required, and some may be removed via hemodialysis, so instructions from medical personnel should be followed. While this medication has no significant interactions with many other drugs, blood concentration changes may occur with specific medications, and consultation with a physician is advised. If there are any unusual symptoms or discomfort during treatment, it is important to consult medical personnel immediately.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, rash, thrombocytopenia, Stevens-Johnson syndrome, exfoliative skin disease, bullous pemphigoid, acute pancreatitis, fatal/non-fatal hemorrhagic or necrotizing pancreatitis, acute renal failure, severe allergic reactions

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• dyspepsia
• dizziness
• weight loss
• hypertension
• hypernatremia

Store this medication in a tightly closed container that is air-tight, at a temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the medication's efficacy for a longer time.

Appearance

Pale yellowish pink, round, biconvex film-coated tablets

Package unit

30 tablets/box (10 tablets/PTP X 3)