Olmesartan Medoxomil and Rosuvastatin Tablets 20/10 mg

Adult dose

Olmesartan medoxomil: The recommended starting dose is 10 mg once daily, taken regardless of meals. If blood pressure is not adequately controlled, the dose may be increased to 20 mg once daily, with a maximum dose of 40 mg per day. The antihypertensive effect typically appears within 2 weeks of treatment initiation, reaching its peak effect at around 8 weeks. If blood pressure is not adequately controlled, it may be administered in combination with a thiazide diuretic.

Child dose

Safety and efficacy in pediatric patients under 18 years have not been established.

This medication can cause serious harm to the fetus and newborn if taken during the second and third trimesters of pregnancy; hence, it should be discontinued immediately upon confirmation of pregnancy. It should not be administered to individuals with a known allergy to this medication or its components, pregnant or potentially pregnant women, breastfeeding mothers, patients undergoing renal dialysis, those with severe renal impairment, patients with severe liver dysfunction, those with biliary obstruction, and patients with muscle disorders. Caution should be taken with patients who have reduced blood volume or low sodium levels, as hypotension may occur, and their condition should be closely monitored. Patients with severe congestive heart failure, who rely on the renin-angiotensin-aldosterone system for kidney function, should be administered this medication with caution because changes in renal function may occur. Patients at risk of hyperkalemia should have their serum potassium levels regularly monitored. Patients with aortic or mitral stenosis, obstruction, and hypertrophic cardiomyopathy may experience exacerbated symptoms due to the blood pressure-lowering effect. This medication may cause muscle-related side effects such as myalgia, myopathy, and rarely, rhabdomyolysis; therefore, patients should consult a physician if they experience severe muscle pain or weakness. Those with a history of alcohol consumption or liver disease should regularly undergo liver function tests as liver dysfunction may occur. During treatment, caution is advised regarding activities such as driving or operating machinery due to the risk of dizziness and other side effects. Additionally, this medication may interact with other drugs, so patients should inform healthcare professionals of any other medications they are taking. Women who are pregnant or planning to become pregnant must consult with healthcare professionals regarding appropriate contraceptive methods, and those who are breastfeeding should also avoid using this medication. Elderly patients or those with impaired renal function require dosage adjustments and monitoring for side effects. In the event of overdose, symptoms such as hypotension and palpitations may occur, so patients should report any abnormal symptoms immediately to their healthcare providers. The safety and efficacy of this medication have not been established in children; therefore, it should not be used in pediatric populations.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, exfoliative dermatitis, pain in mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory distress with cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urinary symptoms

Mild side effects

Headache, dizziness, sensory disturbance, drowsiness, gastroesophageal reflux disease, constipation, dental caries, dyspepsia, gastric ulcer, gastritis, gastroenteritis, musculoskeletal stiffness, atrial fibrillation, hypoglycemia, chest pain, palpitations, joint pain, arthritis, myalgia, rash, pruritus, vomiting, chronic malabsorption syndrome (similar to sprue), alopecia, thrombocytopenia, diarrhea, hematuria, cough, epistaxis, upper respiratory infection, asthma, depression, sleep disorders (including insomnia and nightmares)

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. It is advised to avoid extreme temperatures, storing it at room temperature between 1°C and 30°C.

Appearance

White or light yellow, round film-coated tablets

Package unit

30 tablets/box [30 tablets (10 tablets/Alu-Alu) x 3]