Glupio 15 mg Tablet (Pioglitazone Hydrochloride)

Adult dosage

This medication is taken orally once daily, irrespective of meals. As monotherapy, it should be initiated at a dose of 15 mg once daily, and if effectiveness is insufficient, it may be increased to 30 mg once daily. For concomitant administration with sulfonylureas, metformin, or insulin, the initial dose is also 15 mg once daily, and the maximum recommended dose should not exceed 30 mg once daily.

Children's dosage

There is no experience using this medication in children under 18, so its use is not recommended.

This medication is primarily used for blood sugar control in patients with Type 2 diabetes. This medication may affect heart function, so it should not be used in patients with congestive heart failure or those with a history of heart failure. During treatment, careful monitoring for signs of fluid retention, such as swelling, sudden weight gain, or difficulty breathing, should be performed. If any heart failure symptoms occur, consult a doctor immediately for appropriate treatment, which may include reducing or discontinuing the dose of this medication if necessary. This medication requires the presence of insulin to exert its blood sugar-lowering effects and is not suitable for patients with Type 1 diabetes or diabetic ketoacidosis. It should also not be administered to patients with severely impaired liver function, severe renal impairment, active or past bladder cancer, pregnant women or females who may become pregnant. This medication may cause weight gain and fluid retention, and there may be an increased risk of fractures in women, so caution is required. The risk of hypoglycemia exists, particularly when combined with insulin or sulfonylureas, so symptoms of hypoglycemia should be closely monitored, and the doses of concomitant medications should be adjusted as needed. Regular monitoring of blood sugar levels and liver function tests is necessary during treatment, and any symptoms suggestive of liver damage (fatigue, loss of appetite, jaundice, etc.) should be reported to a physician immediately. Pre-menopausal women should use appropriate contraceptive methods, as ovulation may be stimulated while taking this medication. This medication may interact with other drugs, so patients should inform their physicians or pharmacists about any other medications they are taking. Finally, it is advisable not to use this medication in children or individuals under 18 due to lack of established safety and efficacy.

Serious side effects

Congestive heart failure, edema (including severe edema), difficulty breathing, respiratory distress, severe allergic reactions (hives, severe swelling, chest tightness, cold sweat, paleness), severe skin reactions (severe rash with fever, blisters, skin peeling, mucosal pain in mouth/eyes), liver abnormalities (jaundice, yellowing of the skin or eyes, general malaise), severe neurological symptoms (sudden and very severe headache, lightning headache,

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• muscle pain
• pharyngitis
• abdominal distension
• weight gain
• hypoglycemia
• urinary tract infection
• diarrhea

This medication should be protected from light and moisture and stored at a temperature between 15°C and 30°C. It is best stored in a cool place, approximately 25°C.

Appearance

White, round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle