Linagliptin Metformin Duo Tablet 2.5/1000 mg

Adult dose

This medication is administered twice daily with meals. 1. If not previously treated with metformin: Start with an initial dose of 2.5/500 mg, one tablet twice a day, with an increase to 2.5/1000 mg, one tablet twice a day if necessary. 2. When blood glucose control is difficult with metformin monotherapy: Start with an initial dose of linagliptin 2.5 mg twice daily along with the existing metformin dosing. 3.

This medication may cause a serious side effect known as lactic acidosis, thus it should not be used in certain patients. For example, it should not be administered to patients who are allergic to the components of this medication, have type 1 diabetes, severe renal impairment, acute infections, liver dysfunction, acute alcohol intoxication, or are pregnant women. Due to the risk of hypoglycemia, caution is needed when combining this medication with medications that can induce hypoglycemia, such as sulfonylureas or insulin, and dosage adjustments may be required. Since this medication is excreted through the kidneys, regular monitoring of kidney function is necessary, and it is safer not to use this medication in patients with impaired kidney function. Patients with weak cardiac function should carefully monitor both cardiac and renal function while using this medication. The intake of the medication should be temporarily suspended before and after the administration of iodine contrast agents used in radiological examinations, and it should be resumed only after kidney function has stabilized. It is also safe to discontinue the intake of this medication for a certain period before and after surgery. Rare side effects such as acute pancreatitis or bullous pemphigoid may occur during the use of this medication; therefore, if abdominal pain or skin rashes develop, patients should immediately inform their doctor. Vitamin B12 levels may decrease, so it is advisable to regularly check vitamin B12 status during long-term use. It is recommended that pregnant or breastfeeding women do not use this medication, and if pregnancy is planned, consultation with a doctor is necessary. It is not recommended for children under 10 years of age or adolescents aged 10 to 17 years since safety and efficacy have not been established. Elderly patients may have decreased kidney function, so it is essential to start with the minimum dosage and monitor kidney function frequently. This medication may interact with other drugs; therefore, patients should inform their doctor or pharmacist of any medications they are currently taking. In case of overdose, lactic acidosis may occur, so immediate medical attention is required if symptoms appear. Store out of reach of children and keep away from moisture.

Serious side effects

Hives, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, liver dysfunction (abnormal liver function tests, hepatitis, jaundice), severe allergic reactions, severe skin adverse reactions, respiratory distress, asthma attacks, acute kidney injury, acute myocardial infarction, angina, unstable angina, cardiac arrest, stroke, seizures, confusion, visual disturbances, paralysis, severe myasthenia gravis, depression, acute cholangitis, acute cholecystitis, cholangitis.

Mild side effects

Nasopharyngitis, various immune system disorders, vitamin B12 deficiency, hypoglycemia, taste disorder, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcer formation, abnormal liver function tests, hepatitis, itching, erythema, rash, severe pain and disability-associated arthralgia, rhabdomyolysis, increased lipase, increased amylase, increased blood triglycerides, increased blood creatinine, pruritus, insomnia, depression, dizziness

This medication is sensitive to air and moisture, so it should be stored in a tightly closed container. The storage temperature should be kept between 1 and 30 degrees Celsius at room temperature to maintain the medication's efficacy for an extended period.

Appearance

Bright pink oval film-coated tablet

Package unit

60 tablets/box[(10 tablets/PTPX6)]