Olmesartan Medoxomil/AmLODIPine Besilate/Hydrochlorothiazide Tablet 5/20/12.5mg

Adult dose

The dosage for adults is 1 tablet taken once daily, with or without food. It is advisable to take it at the same time each day (e.g., in the morning). The dosing should follow the titration steps for amlodipine/olmesartan medoxomil/hydrochlorothiazide. The maximum daily dose is 10/40/25mg and adjustments should be made at intervals of more than 2 weeks. For patients with renal impairment, hepatic impairment, or elderly patients, dose adjustments and caution are required.

Child dose

The safety and efficacy of this medication in patients under the age of 18 have not been established; therefore, its use is not recommended.

This medication can cause serious harm to the fetus and newborn when taken during pregnancy, especially in the second and third trimesters, so it should be discontinued immediately upon confirmation of pregnancy. This medication is contraindicated in certain patients, such as those who are allergic to this medication or its components, pregnant or breastfeeding women, patients with severe hypotension or heart valve disease, unstable heart failure following acute myocardial infarction, and patients with severe kidney or liver disease. Patients with reduced blood volume or electrolyte imbalances may experience hypotension in the early stages of taking this medication and should be closely monitored when starting treatment. This medication may affect kidney function, so patients with kidney disease or those who have had a kidney transplant should regularly check their kidney function and electrolyte status through blood tests. Patients with liver disease or specific heart conditions also require special caution when taking this medication, and some patients may react sensitively to it. This medication may interact with other medications, so it is essential to inform healthcare providers of any other medications being taken, particularly with lithium, non-steroidal anti-inflammatory drugs (NSAIDs), and other antihypertensive agents. This medication can cause electrolyte imbalances, so electrolyte levels in the blood should be regularly monitored during treatment to manage symptoms such as hypokalemia or hyperkalemia. Symptoms related to blood pressure reduction, such as dizziness or drowsiness, may occur, so caution is advised when driving or operating hazardous machinery. This medication may cause the skin to become sensitive to sunlight, so care should be taken to avoid ultraviolet exposure during treatment, and any unusual skin reactions should be reported to a healthcare provider immediately. In case of overdose, symptoms such as hypotension and palpitations may occur, requiring immediate medical treatment. The safety and efficacy of this medication in children have not been established, hence it is not recommended. Elderly patients should start on a lower dose considering potential reduced kidney function. During breastfeeding, components of this medication may be transmitted through breast milk, potentially causing adverse reactions in infants, so it is advisable to either discontinue breastfeeding or stop taking the medication. Finally, this medication should be stored in a tightly sealed container away from moisture and heat, and not transferred to another container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in the mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, cough with fever accompanying respiratory distress, yellowing of the skin or eyes (jaundice), generalized malaise, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urinary retention

Mild side effects

• Peripheral edema
• headache
• dizziness
• upper respiratory infection
• rhinitis
• urinary tract infection
• sialadenitis
• leukopenia
• thrombocytopenia
• bone marrow suppression

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is essential to maintain the storage temperature between 1°C and 30°C (room temperature) to preserve its efficacy and safety.

Appearance

White and orange round film-coated tablet

Package unit

30 tablets/box [10 tablets/Alu-Alu × 3]