Arodacapsule (Diacerein)

Adult dose

Adults: Administer 50∼100mg of diacerein per day orally after meals in 1∼2 divided doses. Adjust the dose appropriately according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2-4 weeks is recommended, followed by 50mg twice daily.

This medication should not be used in patients with certain inflammatory bowel diseases. For example, patients with ulcerative colitis or Crohn's disease should not take this medication. Additionally, patients with a history of intestinal obstruction syndrome or unexplained abdominal pain should also refrain from taking this medication. It should be avoided if the patient has an allergic reaction to this drug, its ingredients, or similar class of medications. Patients with liver disease or a history of liver disease, as well as children under 15 years of age, should also refrain from using this medication. This medication contains lactose, therefore, patients with a genetic problem associated with lactose intolerance should avoid using it. Patients with a history of small intestine or colon diseases should exercise caution when using this medication. Pregnant or breastfeeding women should consult with healthcare personnel before taking this medication. Patients aged 65 years and older are advised to reduce the dosage of this medication. While taking this medication, gastrointestinal symptoms such as diarrhea, abdominal pain, and loose stools may occur, and long-term use may increase the risk of gastrointestinal bleeding or ulcers. Rarely, pigmentation may occur in the rectal mucosa. Skin symptoms such as itching, rash, and dermatitis may appear, and liver function may be affected, potentially leading to elevated liver enzyme levels. When taking this medication for an extended period, it is essential to follow the doctor's instructions, and if diarrhea worsens, dehydration and electrolyte imbalance may occur; thus, discontinuation and consultation with healthcare personnel are necessary. Due to the risk of liver damage, if symptoms of liver dysfunction appear, it is crucial to stop taking this medication immediately and follow the doctor's advice, and it is advisable to limit alcohol consumption. This medication may interfere with the absorption of antacids containing calcium, magnesium, or aluminum, so it should be taken at least 2 hours apart from these medications. Caution is advised when taken with diuretics, as the diuretic effect may be enhanced resulting in dehydration or hypokalemia. Additionally, when taken with cardiac glycosides, the risk of arrhythmia may increase, so consultation with healthcare personnel is necessary. Pregnant or breastfeeding women should ideally avoid using this medication as it may affect the fetus or newborn. In the case of an overdose, severe diarrhea may occur, and electrolyte replenishment treatment may be required.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulceration, and perforation), pigmentation of the rectal mucosa, itching, rash, eczema, elevated liver enzymes in serum

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to maintain the storage temperature between 1 and 30 degrees Celsius, at room temperature.

Appearance

A hard capsule with a white upper part and a yellow lower part filled with a brown-yellow content

Package unit

30 capsules/bottle, 500 capsules/bottle