Pyrizone Tablet (Pioglitazone Hydrochloride)

Adult dosage

This medication is taken orally once daily, regardless of meals. For monotherapy, it may start at 15 mg once daily, and if the effect is insufficient, it can be increased to 30 mg once daily. For combination therapy, it is also administered at an initial dose of 15 mg once daily. The maximum recommended dose should not exceed 30 mg once daily.

Children's dosage

There is no experience using this medication in children under 18 years, so its administration is not recommended.

This medication may cause or worsen heart failure in some patients; therefore, when starting treatment or increasing dosage, careful observation for symptoms of heart failure such as sudden weight gain, shortness of breath, and edema is required. Patients with heart failure or a history of heart failure should not use this medication, and if symptoms appear, they should consult a healthcare professional immediately for appropriate treatment. This medication can cause fluid retention, so caution is especially needed for patients with heart disease; consider dosage adjustment or discontinuation if edema or signs of heart failure appear. If symptoms such as hematuria, urinary obstruction, or urgency appear during treatment, there may be a risk of bladder cancer, and the physician should be notified immediately. Patients with genetic lactase deficiency should not take this medication. This medication should not be administered to patients with heart failure, bladder cancer, liver disease, severe kidney disease, diabetic ketoacidosis, type 1 diabetes, pregnant women, or women who may become pregnant. When used in combination with other oral hypoglycemic agents, there may be a risk of hypoglycemia, so dosage adjustment may be necessary. Pre-menopausal women should use effective contraception, as this medication may stimulate ovulation and pose a risk of pregnancy. During treatment, regular monitoring of blood sugar and liver function tests is recommended, and any abnormal symptoms should be reported to healthcare personnel promptly. Weight gain and edema may occur during the use of this medication, and patients with heart disease should closely monitor for edema and signs of heart failure. Elderly patients and patients with kidney or liver function impairment should use this medication with increased caution. In case of overdose, there might not be specific symptoms; however, appropriate treatment should be provided according to clinical signs. The safety and efficacy of this medication have not been established in children, so it is not recommended for use in this population. There may be drug interactions, so any other medications being taken should be reported to healthcare personnel.

Serious side effects

• Congestive heart failure
• worsening heart failure
• excessive and rapid weight changes
• shortness of breath
• severe edema
• elevated blood pressure
• visible hematuria
• urinary dysfunction
• urgency
• bladder cancer

Mild side effects

• Upper respiratory tract infection
• headache
• sinusitis
• muscle pain
• pharyngitis
• abdominal bloating
• weight gain
• urinary tract infection
• hypoglycemia
• back pain

This medication should be stored in a container protected from light and air, and should be kept away from moisture. The recommended storage temperature is between 15 to 30 degrees Celsius, ideally at room temperature around 25 degrees.

Appearance

White round tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle