Azathioprine Tablets 50 mg (Azathioprine)

Adult dose

After kidney transplantation: Administer azathioprine orally at an initial dose of 3-5 mg/kg of body weight per day and a maintenance dose of 0.5-2 mg/kg of body weight per day. In patients with creatinine clearance of 20 mL/min or less, the dose must not exceed 1.5mg/kg of body weight per day. Autoimmune diseases: For conditions other than chronic active arthritis, administer 2.0-2.5 mg/kg of body weight per day. For chronic active arthritis, administer 1.0-1.5mg/kg of body weight per day. The tolerated and effective doses vary among patients; therefore, the dose should be carefully adjusted to achieve the optimal therapeutic effect. If the condition does not improve after 12 weeks, consider discontinuing treatment. Adjust the dose as appropriate according to age and symptoms.

This medication should not be used in certain patients. For example, patients who are allergic to this drug or similar drugs, or who have experienced allergic reactions in the past, or those with severe liver or kidney diseases, bone marrow dysfunction, severe infections, or pancreatitis should not take this medication. Additionally, patients with very low white blood cell counts, pregnant women, women who may become pregnant, or nursing mothers should not use this medication. Patients with genetic lactose metabolism issues should also avoid this drug. This drug should be administered with caution in patients with reduced bone marrow function, infections, bleeding tendencies, or liver or kidney disorders. Caution is also necessary in patients with chickenpox or those taking certain medications. During treatment with this drug, patients may become more susceptible to infections, so if symptoms of infection appear, they should consult their doctor immediately. Additionally, this drug may decrease blood cell counts, increasing the risk of anemia or bleeding, and a variety of side effects such as liver dysfunction, pancreatitis, skin rash, and respiratory issues may occur. Regular blood tests and liver function tests should be conducted during treatment, and immediate consultation with a doctor is required if abnormal signs are detected to consider dosage adjustment or discontinuation. Prolonged use of this medication may increase the risk of side effects, thus it should be managed carefully, particularly due to an increased risk of infections or tumor development. Pregnant or nursing women should not take this medication, and if it is absolutely necessary to use it, breastfeeding should be discontinued. Special attention is needed for children and the elderly, adjusting the dosage while closely monitoring kidney and liver function status. In case of overdose, symptoms such as blood cell reduction, infections, bleeding, vomiting, and diarrhea may occur, and immediate medical treatment should be sought. This medication has many drug interactions, so if other medications are being taken, it is essential to inform the doctor or pharmacist, particularly when used in combination with certain antibiotics, immunosuppressants, or anticoagulants. Finally, this medication should be kept out of reach of children and stored in its original container to prevent quality deterioration or misuse.

• Infection
• progressive non-Hodgkin lymphoma
• skin cancer
• sarcoma
• cervical cancer
• bone marrow dysfunction
• leukopenia
• thrombocytopenia
• anemia
• neutropenia

This drug should be stored in a sealed container to protect it from air and moisture, and it is recommended to keep it at a temperature between 1 to 30 degrees Celsius at room temperature. It is also helpful to store it in a dark place away from direct sunlight to maintain the efficacy of the medication.

Appearance

Pale yellow round film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 100 tablets/bottle, PTP - 100 tablets/box [10 tablets/PTP x 10 pieces]