Olmesartan Medoxomil/Amlodipine Besylate/Hydrochlorothiazide Tablets 5/20/12.5 milligrams

Adult dose

The recommended dosage is one tablet once daily, taken with water regardless of meals. It is advisable to take it at the same time each day (e.g., in the morning). The maximum dosage is Amlodipine/Olmesartan Medoxomil/Hydrochlorothiazide at 10/40/25mg. Dosage escalation steps are as follows: 5/20/0mg → 5/20/12.5mg → 5/40/0mg → 5/40/12.5mg → 5/40/25mg.

Child dose

Safety and efficacy for pediatric patients under 18 years have not been established, and the use of this medication is not recommended.

This medication can cause serious harm or death to the fetus and newborn if used during the second and third trimesters of pregnancy, so treatment must be discontinued immediately upon confirmation of pregnancy. Patients with allergies to any ingredients or related drugs, those who are pregnant or breastfeeding, or those with severe hypotension, heart valve problems, unstable heart failure after acute myocardial infarction, or severe kidney or liver impairment should not take this medication. Patients with reduced blood volume or renal function may experience hypotension initially when starting this medication. Their condition should be closely monitored, and appropriate measures taken as needed. This medication may affect kidney function, so patients dependent on renal function, kidney transplant recipients, or those with renal artery stenosis should exercise caution when using it. Patients with impaired liver function or liver disease are at risk for hepatic coma, and this medication is not recommended for those with severe liver impairment. During treatment, blood pressure may drop too low, causing dizziness or orthostatic hypotension, so caution is advised with activities such as heights or driving. This medication can cause electrolyte imbalances, so electrolyte levels should be regularly monitored through blood tests. Particular caution is necessary when taking this medication with potassium supplements or potassium-sparing diuretics, as potassium levels may increase. Numerous drug interactions may occur; consult a physician or pharmacist if taking other medications. Efficacy and safety for children and adolescents under 18 years have not been established, so its use is not recommended. In older adults, dosage should be adjusted with consideration for reduced renal and liver function, and caution should be exercised during use. In case of overdose, symptoms such as hypotension, palpitations, and bradycardia may occur, necessitating immediate treatment and monitoring in a hospital. This medication should be stored away from moisture, heat, and direct sunlight in a place inaccessible to children. Skin photosensitivity reactions may occur during treatment, so care should be taken to avoid excessive sun exposure. Women who are pregnant or planning to become pregnant should consult a physician before taking this medication, and breastfeeding mothers should either avoid it or consult a specialist.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis.

Mild side effects

• Peripheral edema
• headache
• dizziness
• upper respiratory infection
• nasopharyngitis
• urinary tract infection
• sialadenitis
• leukopenia
• thrombocytopenia
• bone marrow suppression

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is important to keep the storage temperature between 1°C and 30°C to maintain the medication's effectiveness and safety over time.

Appearance

White-orange round film-coated tablet

Package unit

30 tablets/Alu-Alu[(10 tablets/Alu-Alu × 3)]