Donepezil Tablets 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. If strange dreams, nightmares, or insomnia occur, consider morning administration. Administer 5 mg for 4-6 weeks, and after evaluating clinical response, it may be increased to 10 mg. If increasing to 10 mg daily, be cautious of gastrointestinal adverse reactions. Underweight elderly women (85 years or older) should take 5 mg daily.

Child dose

There is no experience with the use in pediatric patients.

This medication contains donepezil hydrochloride as the active ingredient and is used for the treatment of Alzheimer's type dementia symptoms. This medication should not be administered to certain patients. For example, individuals who are allergic to this medication or its components, women who are pregnant or may become pregnant, and nursing mothers should not take this medication. Additionally, since it contains lactose, individuals with lactose intolerance or genetic lactose metabolism disorders should not take this medication. Patients with heart disease or heart conduction disorders should be cautious as this medication may cause heart problems such as bradycardia or arrhythmias. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be careful as this medication may increase gastric acid secretion, worsening ulcer symptoms. Patients with a history of asthma or obstructive lung disease should be administered cautiously as bronchoconstriction and increased mucus secretion may worsen symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should be cautious as this medication may worsen symptoms. This medication contains Yellow No. 5 dye, and individuals allergic to this ingredient should use it with caution. Various adverse reactions may occur while taking this medication, and in severe cases may include fainting, heart problems, gastrointestinal bleeding, liver dysfunction, cerebrovascular disorders, movement disorders, muscle pain, respiratory distress, acute pancreatitis, and kidney failure. Neurological and gastrointestinal adverse reactions such as nausea, vomiting, diarrhea, dizziness, insomnia, hallucinations, aggressive behavior have also been reported. This medication should only be used for patients with Alzheimer's type dementia and is not approved for other forms of dementia or memory disorders. Regularly evaluate the therapeutic effect, and if there is no effect, it is advisable to discontinue use. Patients with cardiovascular diseases or a history of QT interval prolongation may require cardiac monitoring. This medication may affect the ability to drive or operate machinery, so caution is advised. Additionally, it may interact with certain medications, so if there are any concurrent medications, consult with a doctor or pharmacist. Pregnant or nursing women are advised to avoid this medication, and if absolutely necessary, should do so under the guidance of a specialist. Safety in children has not been established, so it should not be used in pediatric patients. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur; therefore, seek medical attention immediately, and atropine can be used as an antidote. This medication should be kept out of reach of children, and transferring to another container should be avoided.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, sloughing skin, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• hallucinations
• excitement

This medication should be stored in a tightly closed container to prevent air exposure and should be kept at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

Yellow round film-coated tablets

Package unit

Bottle package - 30 tablets/bottle, Bottle package - 100 tablets/bottle