Orphenesemi Controlled-release Tablet

Adult dose

The dosage should be adjusted based on the patient’s level of pain and treatment response. An initial dose of 2 tablets is recommended, and thereafter the dosing interval should be at least 12 hours apart, not exceeding 8 tablets per day. To avoid prolonged use of this medication beyond what is necessary, if prolonged treatment is required due to the nature and severity of the disease, regular monitoring should be performed to confirm the continuation of this medication.

This medication may burden the liver, so individuals who usually consume alcohol daily should consult a physician or pharmacist before taking it. If severe rashes, blisters, or red spots appear on the skin during treatment, discontinue use immediately and inform healthcare personnel. The ingredients in this medication can cause seizures, so patients with a history of seizures or at high risk of seizures should use it cautiously. Additionally, taking this medication with certain antidepressants or other pain relievers, narcotic drugs may increase the risk of seizures, so it is essential to consult a professional. Patients with asthma who have weak respiratory function are at risk of severe respiratory suppression when taking this medication, so it should be administered in a facility equipped with medical equipment. Using this medication with alcohol or sedatives, which also depress the central nervous system, can lead to severe drowsiness, respiratory suppression, or even coma; caution is necessary. Patients with head injuries or brain diseases should use this medication carefully as it may increase intracranial pressure. This medication has the potential for dependence; thus, dosages and duration should be adjusted according to a physician's instructions when used for a long time. Especially, patients with weak liver function are at risk of liver damage, so they must consult healthcare personnel before taking this medication. Children, especially those under 12 years old or adolescents under 18 years old who have undergone tonsillectomy, should not use this medication. Pregnant or breastfeeding women should consult a physician before taking this medication, as it may pose risks to the fetus or newborn. Caution is advised when driving or operating machinery, as drowsiness or dizziness may occur. In cases of overdose, severe respiratory suppression or liver damage may occur, so immediate emergency treatment is required if symptoms appear. During the use of this medication, care must be taken to avoid taking other pain relievers or medications containing acetaminophen concurrently.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, severe rash with fever, blisters, skin peeling, painful mucous membranes of the mouth/eyes, severe allergic reactions, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme drowsiness, liver abnormalities (jaundice), sudden and severe reactions

Mild side effects

• Weakness
• fatigue
• flushing
• stiffness
• fainting
• withdrawal symptoms
• hypertension
• worsening hypertension
• hypotension
• arrhythmia

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. Additionally, it is best to store the medication at room temperature between 1°C and 30°C.

Appearance

Pale yellow round controlled-release film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle