New Mepirine Tablets (Glymepiride)

Adult dosage

This medication is administered orally once daily. It should be taken before breakfast or just prior to the first meal. The initial dose should be 1 mg of glymepiride, which can be increased by 1 mg at intervals of 1 to 2 weeks. Generally, dosages above 4 mg do not provide additional effects, but if necessary, doses of 6 mg or 8 mg may be achievable. If a daily dosage of 4 mg fails, consider insulin therapy.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or diabetic coma. Individuals allergic to this medication or its components should also avoid taking it. There is no experience using this medication in patients with severely impaired liver or kidney function, so switching to insulin therapy is recommended. In pregnant or potentially pregnant women, as well as breastfeeding women, it is safest not to use this medication. Patients with severe infections, those undergoing surgery, or those with significant trauma may require insulin therapy, so caution is necessary. When gastrointestinal disturbances such as diarrhea or vomiting occur, there is a risk of hypoglycemia due to inadequate absorption of food, so care is needed. This medication contains lactose, so individuals with lactose intolerance or related genetic disorders should not take it. During the initial stages of treatment, the risk of hypoglycemia is high, thus blood glucose levels should be monitored closely, especially in the elderly, those with poor nutritional status, or those with irregular eating habits. Imbalances in physical activity and food intake, changes in diet, and alcohol consumption may also increase the risk of hypoglycemia, hence caution is necessary. Patients with impaired liver or kidney function, other endocrine diseases, and those taking multiple medications should consult their doctor as they may have an increased risk of hypoglycemia. This medication contains Yellow No. 4 (tartrazine), so those allergic to this component should use it cautiously. Symptoms of hypoglycemia can include headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and loss of consciousness. In severe cases, it may lead to seizures or coma. Transient visual disturbances or blurred vision may occur, and gastrointestinal symptoms such as nausea, vomiting, abdominal pain, and diarrhea may also appear. Serious side effects like liver dysfunction, blood abnormalities, and allergic reactions may occur rarely, so if any abnormal symptoms arise, medical personnel must be notified immediately. When taking this medication, regular meals, exercise, and weight management are important, and if hypoglycemia occurs, sugars should be consumed immediately to alleviate symptoms. Inform the doctor about all medications being taken, as concomitant use of other drugs may affect blood glucose control. In cases of pregnancy or breastfeeding, this medication may be harmful to the fetus or newborn, so it is advisable not to use it. For children under 18 years of age, safety and efficacy have not been established, so it is recommended not to use it. Elderly patients may experience delayed drug excretion due to reduced kidney function, thus requiring dosage adjustments. In the case of overdose, severe hypoglycemia may occur, requiring immediate medical attention and possibly emergency measures such as glucose injections.

Serious side effects

• Hives
• severe swelling (edema)
• chest tightness
• difficulty breathing
• hypotension
• anaphylaxis
• angioedema
• Stevens-Johnson syndrome
• liver function abnormalities
• jaundice

Mild side effects

• Headaches
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• reduced alertness or activity

This medication should be stored in a tightly sealed container to avoid exposure to air and moisture. It is safest to store it at room temperature, between 1°C and 30°C.

Appearance

Green rectangular tablet

Package unit

100 tablets/bottle