Glupen Tablet 4 mg (Glymepiride)

Adult dose

Individual adjustments are made for each patient. Swallow without chewing with more than 1/2 cup of water. This medication is taken orally once daily. It should be taken before breakfast or just before the first meal. It is very important not to skip meals after taking this medication. 1. Monotherapy 1) Initial dosage and adjustment For patients who have never been treated with medication before, the initial dose is 1 mg of glymepiride taken once daily. If necessary, increase the dose by 1 mg at intervals of 1 to 2 weeks.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or severe liver or kidney dysfunction. Additionally, patients who are allergic to this medication, its components, or sulfonylurea drugs should not take it. It is preferable for pregnant or breastfeeding women not to use this medication, and it is advised to switch to insulin therapy if necessary. Patients with severe infections or those undergoing pre- or post-surgery or those who have suffered severe trauma should also be recommended to switch to insulin treatment instead of this medication. Patients with gastrointestinal disorders should be cautious due to the risk of hypoglycemia caused by food absorption issues. Patients with lactose intolerance or certain genetic metabolic disorders should not take it due to the lactose contained in this medication. During the first week of taking this medication, there is a high risk of hypoglycemia, so blood sugar levels should be monitored closely. Especially in elderly patients, those with poor nutritional status or irregular meals, frequent alcohol consumers, and patients with reduced liver or kidney function require extra caution. Additionally, there may be an increased risk of hypoglycemia in patients with other endocrine disorders or taking multiple medications, so consultation with a doctor is essential. This medication can cause hypoglycemia, which may present symptoms such as headaches, severe hunger, dizziness, confusion, drowsiness, and loss of consciousness, so these symptoms should prompt immediate intake of sugar or notification to healthcare personnel. In the initial phase, symptoms like blurred vision or dyspepsia, liver dysfunction, blood abnormalities, or allergic reactions may occur, and contact with a specialist should be made if any abnormal symptoms arise. When taking this medication, maintaining regular meals, exercise, and weight management is important, and preparations should be made to immediately consume sugar in case of hypoglycemia. Both patients and their families should fully understand the symptoms and prevention of hypoglycemia. Additionally, special situations such as stress, surgery, or infections may impair blood sugar control, and insulin therapy may sometimes need to be transitioned. When taking this medication with other drugs, the effectiveness of this medication may change, so all other medications being taken should be disclosed to doctors or pharmacists, and attention should be paid to drug interactions. Particularly, concomitant use with beta-blockers, antibiotics, anticoagulants, or steroids may cause significant changes in blood sugar. In cases of overdose, severe hypoglycemia can occur, necessitating immediate emergency treatment, including inducing vomiting, administering activated charcoal, or intravenous glucose. This medication has not been shown to be safe and effective for children, and dosage adjustments may be necessary for the elderly considering kidney function decline. Finally, this medication should be stored out of reach of children and kept in its original container, and rare but serious side effects have been reported in clinical trials and post-marketing surveillance, so immediate consultation with healthcare personnel should be made for any abnormal symptoms.

Serious side effects

• Hives
• severe swelling (angioedema)
• breathing difficulties
• hypotension
• chest tightness
• vascular edema
• anaphylaxis
• Stevens-Johnson syndrome
• liver dysfunction
• jaundice

Mild side effects

Headache, severe hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggression, decreased concentration, reduced motivation, depression, confusion, speech anomalies, aphasia, visual disturbances, tremors, incomplete paralysis, sensory disturbances, dizziness, weakness, loss of self-control, mental confusion, drowsiness, shallow breathing, bradycardia, sweating, cold and clammy skin, tachycardia, hypertension, palpitations, angina, arrhythmia, blurred vision, fullness or pressure in the upper abdomen, gastrointestinal discomfort.

This medication may be sensitive to air and moisture, so it is important to store it in a tightly closed container. Additionally, it should be stored at room temperature, neither too cold nor too hot, specifically between 1 to 30 degrees Celsius. This will help maintain the medication's effectiveness and safety.

Appearance

Pale blue rectangular tablet

Package unit

30 tablets/bottle, 100 tablets/bottle