Donepezil Tablets 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Adult: Donepezil hydrochloride should be administered at a dose of 5 mg once daily at bedtime. If unusual dreams, nightmares, or sleep disturbances occur, consideration can be given to taking this medication in the morning. The concentration of donepezil reaches a steady state after 15 days of administration, so 5 mg should be maintained for 4 to 6 weeks. After evaluating clinical response during this period, the dose can be increased to 10 mg. If increasing the dose to 10 mg, vigilance is necessary regarding gastrointestinal adverse reactions.

Child dose

Pediatric: No experience using this in children.

This medication contains donepezil hydrochloride as the main ingredient and is primarily used to alleviate symptoms of Alzheimer's disease. It should not be administered to certain patients, including those who are allergic to donepezil or any of its components, pregnant women or those who may become pregnant, and breastfeeding women. Additionally, patients with genetic lactose intolerance, deficiency of lactase, or glucose-galactose malabsorption should not use this medication. Patients with heart diseases, especially those with bradycardia or heart conduction disorders, should exercise caution as this medication can slow heart rate or cause arrhythmia. Furthermore, patients with a history of peptic ulcers or those taking non-steroidal anti-inflammatory drugs should be cautious due to the potential risk of gastrointestinal bleeding or worsening of ulcers. Patients with asthma or chronic obstructive pulmonary disease may also experience exacerbation of their symptoms while taking this medication. This medication may also affect the brain and nervous system, with potentiation of symptoms in patients with extrapyramidal disorders such as Parkinson's disease. Additionally, individuals allergic to Yellow No. 5 pigment should inform their healthcare provider before taking this medication. During treatment with this medication, serious side effects such as syncope, bradycardia, heart block, peptic ulcer, liver dysfunction, seizures, movement disorders, muscle spasms, difficulty breathing, acute pancreatitis, and acute renal failure may occur, and any unusual symptoms should prompt immediate consultation with a healthcare professional. Common side effects include loss of appetite, hallucinations, agitation, aggressive behavior, anxiety, insomnia, drowsiness, increased libido, talking more than usual, mania, nightmares, nervousness, nonsensical speech, delusions, depression, confusion, indifference, hyperactivity, dizziness, insomnia, tremors, stupor, palpitations, hypertension, hypotension, atrial fibrillation, diarrhea, nausea, vomiting, constipation, increased salivation, dysphagia, fecal incontinence, rash, itching, muscle cramps, and myalgia. This medication can influence heart rate, so patients with heart diseases or a history of prolonged QT interval require regular monitoring, including electrocardiogram tests. Moreover, caution is advised when driving or operating machinery while using this medication, especially during initial treatment or dose adjustments as dizziness or fatigue may occur. Since this medication is metabolized in the liver, dosage adjustment and careful monitoring are necessary for patients with liver dysfunction. Additionally, this medication can interact with several drugs, so it is essential to inform your doctor or pharmacist if you are taking any other medications. Pregnant or breastfeeding women are advised against using this medication unless absolutely necessary, and should make a careful decision after consulting a doctor. Safety for use in children has not been established, so it is not to be used in children. In the case of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, and seizures may occur, and emergency treatment should be sought with atropine as an antidote. This medication should be kept out of reach of children, and transferring it to other containers can lead to degradation in quality or accidents, so caution is necessary.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attack, cough accompanied by fever and breathing difficulties, yellowing of skin or eyes (jaundice), extreme fatigue throughout the body, sudden and severe headaches, lightning-like headache, seizures, confusion, visual disturbances, paralysis, urination issues

Mild side effects

• Loss of appetite
• hallucinations
• agitation
• aggressive behavior
• anxiety
• insomnia
• drowsiness
• increased libido
• talkativeness
• mania

This medication should be stored in a tightly closed container that allows good air circulation, and it is best to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage can prolong the medication's effectiveness.

Appearance

Yellow circular film-coated tablets

Package unit

30 tablets/bottle